Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints.
Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints.
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DOI：
10.1016/j.cobeha.2015.11.017
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发表时间：
2016-02
影响因子：
5
通讯作者：
Vom Saal FS
中科院分区：
文献类型：
--
作者：
Palanza P;Nagel SC;Parmigiani S;Vom Saal FS
在使用的大约 85,000 种化学品中，有 1000 种已被确定具有破坏正常内分泌功能的能力。在大脑分化的关键时期（产前和新生儿生活），通过母亲接触内分泌干扰化学物质（EDC）可以改变两性行为的发展过程。双酚 A (BPA) 是一种大量用于塑料、树脂和其他产品的化学物质，几乎每个接受检查的人都可检测到 BPA。 BPA 具有雌激素活性，是研究最多的 EDC 之一。我们使用与人类暴露相关的剂量水平回顾了啮齿动物研究的证据。 BPA 会改变行为并消除或在某些情况下逆转未接触过 BPA 的动物中观察到的性别二态性行为。
Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical period in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. Bisphenol A (BPA) is a very high volume chemical used in plastic, resins and other products, and virtually everyone examined has detectable BPA. BPA has estrogenic activity and is one of the most studied EDCs. We review evidence from studies in rodents using dose levels relevant to human exposure. BPA alters behavior and eliminates or in some cases reverses sexually dimorphic behaviors observed in unexposed animals.