SYMPATHETIC NERVOUS-SYSTEM EFFECTS ON FELINE BLADDER WALL COMPLIANCE THROUGHOUT CONTINENCE
SYMPATHETIC NERVOUS-SYSTEM EFFECTS ON FELINE BLADDER WALL COMPLIANCE THROUGHOUT CONTINENCE
复制标题
DOI：
10.1111/j.1748-1716.1995.tb09945.x
复制
发表时间：
1995-09-01
期刊：
影响因子：
--
通讯作者：
VAUGHAN, CW
中科院分区：
文献类型：
--
作者：
KHADRA, MH;SATCHELL, PM;VAUGHAN, CW
膀胱是一个顺应性器官，高度顺应性对于有用的尿液储存至关重要。交感神经系统通过增加膀胱顺应性来促进尿液储存的程度尚不清楚。本研究的目的是确定交感神经系统增加膀胱壁顺应性的膀胱体积范围。在仰卧的麻醉猫中，膀胱充盈速度是自然充盈速度的两倍，失禁周期分为五个阶段中断。这些阶段是当膀胱变成球形时，在前驱收缩期间，在非排尿性收缩开始后不久，大约在尿失禁周期的三分之二，就在排尿之前。在每次中断期间，膀胱容量保持不变，同时记录骨盆神经传入活动和膀胱压力。在静脉输注三甲撒芬之前和期间进行记录，由此产生的部分神经节阻滞使动脉压降低了三分之一。当交感驱动被短暂阻断时，膀胱压力和传入神经活动显著增加，表明存在普遍的净交感抑制效应促进膀胱壁放松。这种效果在前驱宫缩期间观察到，并持续到排尿开始。这种净交感神经抑制作用是治疗膀胱贮积障碍的潜在治疗途径。
The urinary bladder is a compliant organ, high compliance being essential for useful urine storage. The extent to which the sympathetic nervous system promotes the storage of urine by increasing bladder compliance is unclear. The aim of the present study was to determine the range of bladder volumes over which the sympathetic nervous system increased bladder wall compliance. In supine, anaesthetized cats, the bladder was filled at twice the rate of natural filling, the continence cycle being interrupted at five stages. These stages were when the bladder had become globular, during prodromal contractions, soon after non-micturating contractions had commenced, approximately two-thirds of the way through the continence cycle and just prior to micturition. During each of these interruptions, bladder volume was held constant while pelvic nerve afferent activity and bladder pressure were recorded. Recordings were obtained before and during the intravenous infusion of trimethaphan, the resulting partial ganglion blockade decreasing arterial pressure by a third. Bladder pressure as well as afferent nerve activity increased significantly when the sympathetic drive was transiently blocked, indicating that there had been a prevailing net sympatho-inhibitory effect promoting bladder wall relaxation. This effect was observed during prodromal contractions and continued until the onset of micturition. This net sympatho-inhibitory effect is a potential therapeutic path for the treatment of bladder storage disorders.