Gestational Weight Gain and Overweight in Children Aged 3-6 Years.
Gestational Weight Gain and Overweight in Children Aged 3-6 Years.
复制标题
DOI：
10.2188/jea.je20140149
复制
发表时间：
2015
影响因子：
4.7
通讯作者：
Ren A
中科院分区：
文献类型：
--
作者：
Guo L;Liu J;Ye R;Liu J;Zhuang Z;Ren A
确定考虑孕前BMI后，妊娠期体重增加（GWG）是否与儿童期超重几率增加相关。在一项基于中国婚前和围产期保健系统的前瞻性队列研究中，获得了100612对母婴的数据。主要暴露量为GWG，作为连续变量和分类变量。结果测量是超重，定义为3-6岁儿童的体重指数（BMI）的年龄和性别特异性截止值。母亲GWG每增加1 kg，儿童平均BMI增加0.009（95%置信区间[CI]：0.007-0.010，P < 0.001）;在孕前超重/肥胖母亲亚组中，儿童BMI增加0.028（95% CI：0.017-0.039，P < 0.001）。当以足够的GWG作为参考时，过量的GWG在儿童期超重中起重要作用，比值比（OR）为1.21（95%CI，1.12-1.29）。在怀孕前超重/肥胖和怀孕期间体重增加过多的母亲的孩子中，风险最高（OR 2.22; 95%CI，1.79-2.76）。更大的母亲GWG与更大的后代BMI相关，母亲在怀孕前超重/肥胖并在怀孕期间体重增加过多的儿童超重的风险增加了一倍。因此，在怀孕期间保持适当的体重增加和预防母亲怀孕前超重/肥胖应该是预防儿童超重/肥胖的策略。
To determine whether gestational weight gain (GWG) was associated with increased odds of childhood overweight after accounting for pre-pregnancy BMI. In a prospective cohort study based on a premarital and perinatal health care system in China, data of 100 612 mother-child pairs were obtained. The main exposure was GWG as both a continuous and categorical variable. The outcome measure was overweight, defined by age- and sex-specific cutoff values for body mass index (BMI) in children aged 3–6 years. A 1-kg increase in maternal GWG was associated with an increase of 0.009 (95% confidence interval [CI]: 0.007–0.010, P < 0.001) in children’s mean BMI; in the subgroup of pre-pregnancy overweight/obese mothers, the increase in children’s BMI was 0.028 (95% CI, 0.017–0.039, P < 0.001). Excessive GWG played an important role in childhood overweight when adequate GWG was used as the reference, with an odds ratio (OR) of 1.21 (95% CI, 1.12–1.29). The risk was highest (OR 2.22; 95% CI, 1.79–2.76) in the children of mothers who were overweight/obese before pregnancy and gained excessive weight during pregnancy. Greater maternal GWG was associated with greater offspring BMI, and the risk of overweight was doubled in children whose mothers were overweight/obese before pregnancy and gained excessive weight during pregnancy. As a result, maintenance of appropriate weight gain during pregnancy and prophylaxis of maternal overweight/obesity before pregnancy should be a strategy for preventing childhood overweight/obesity.