Acute interstitial nephritis due to nicergoline (Sermion®)
Acute interstitial nephritis due to nicergoline (Sermion®)
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DOI：
10.1159/000064096
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发表时间：
2002-09-01
期刊：
影响因子：
2.5
通讯作者：
Bang, BK
中科院分区：
文献类型：
--
作者：
Kim, MJ;Chang, JH;Bang, BK
我们报告一例急性间质性肾炎（AIN）由于尼麦角碱（sermicion (R)）。一位50岁的病人因发烧和急性肾衰竭而住进我院。入院前在眼科因视网膜静脉闭塞服用尼麦角林和苯达唑赖氨酸。此后，他出现间歇性发热和皮疹。入院时，临床症状（如关节痛和发热）和实验室检查结果（如嗜酸性粒细胞增多和肾功能衰竭）提示AIN，肾活检病理结果证实了这一点。淋巴细胞转化试验显示对尼麦角碱呈阳性反应。治疗包括停用尼麦角林和静脉注射甲基强的松龙，肾功能完全恢复。据我们所知，这是第一次报道尼古丁相关的AIN。版权所有(C) 2002 S. Karger AG，巴塞尔。
We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion(R)). A 50-year-old patient admitted to our hospital for fever and acute renal failure. Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department. Thereafter, he experienced intermittent fever and skin rash. On admission, clinical symptoms (i.e. arthralgia and fever) and laboratory findings (i.e. eosinophilia and renal failure) suggested AIN, and which was confirmed by pathologic findings on renal biopsy. A lymphocyte transformation test demonstrated a positive result against nicergoline. Treatment was consisted of withdrawal of nicergoline and intravenous methylprednisolone, and his renal function was completely recovered. To our knowledge, this is the first report of nicergoline-associated AIN. Copyright (C) 2002 S. Karger AG, Basel.