Progress and challenges in predicting protein interfaces.
Progress and challenges in predicting protein interfaces.
复制标题
DOI：
10.1093/bib/bbv027
复制
发表时间：
2016-01
影响因子：
9.5
通讯作者：
Deane CM
中科院分区：
文献类型：
--
作者：
Esmaielbeiki R;Krawczyk K;Knapp B;Nebel JC;Deane CM
大多数生物过程是通过蛋白质-蛋白质相互作用介导的。确定参与此类相互作用的残基可以提高我们对分子机制的理解并促进治疗方法的开发。识别相互作用残基的实验方法（例如诱变）既昂贵又耗时，因此，用于此目的的计算方法可以简化传统的流程。在这里，我们回顾计算蛋白质界面预测领域。由于抗体的结合机制截然不同，我们区分了针对一般蛋白质的方法和针对抗体的方法。我们根据所需的输入和预测原则分层组织当前可用的多种方法，以提供该领域的概述。
The majority of biological processes are mediated via protein–protein interactions. Determination of residues participating in such interactions improves our understanding of molecular mechanisms and facilitates the development of therapeutics. Experimental approaches to identifying interacting residues, such as mutagenesis, are costly and time-consuming and thus, computational methods for this purpose could streamline conventional pipelines. Here we review the field of computational protein interface prediction. We make a distinction between methods which address proteins in general and those targeted at antibodies, owing to the radically different binding mechanism of antibodies. We organize the multitude of currently available methods hierarchically based on required input and prediction principles to provide an overview of the field.
影响因子：
14.9
作者：
Neuvirth, Hani;Heinemann, Uri;Birnbaum, David;Tishby, Naftali;Schreiber, Gideon
通讯作者：
Schreiber, Gideon