High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma
High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma
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DOI：
10.1111/pin.12724
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发表时间：
2018-11-01
影响因子：
2.2
通讯作者：
Noguchi, Masayuki
中科院分区：
文献类型：
--
作者：
Sakashita, Mai;Sakashita, Shingo;Noguchi, Masayuki
探讨卵巢癌免疫反应性抗原结构域2（OCIAD 2）在肺腺癌中的临床病理意义。应用免疫组化方法检测191例手术切除的肺腺癌组织中OCIAD 2的表达。使用H-评分定量OCIAD 2表达，并将其分为高或低。OCIAD 2蛋白的高表达与乳腺癌的血管浸润（P = 0.0018）、淋巴管浸润（P = 0.049）、T因子（P = 0.0024）和病理分期（P = 0.0003）显著相关。OCIAD 2高表达与总生存期（OS）较差显着相关（n = 191，P = 0.0325）。在周围型肺腺癌（n = 161）中，OCIAD 2高表达与OS较差（P = 0.0214）和无病生存率较差（P = 0.0496）显著相关。原位腺癌（AIS）和微创腺癌（MIA）的OCIAD 2表达较浸润性腺癌弱。在根据Noguchi分类法分类的最大尺寸为2 cm或更小的小腺癌中（n = 79），浸润性腺癌显示出比非浸润性腺癌显著更高的OCIAD 2表达（P = 0.0007）。有趣的是，OCIAD 2甚至在肿瘤内也不均匀地表达，并且其在浸润区域的表达高于原位扩散区域。我们的研究结果表明，OCIAD 2可能是一个有用的肺腺癌的预后生物标志物。
The clinicopathological implications of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) in lung adenocarcinoma were investigated. The expression of OCIAD2 in 191 surgically resected lung adenocarcinomas was examined using immunohistochemistry. OCIAD2 expression was quantified using the H-score and dichotomized as high or low. High OCIAD2 protein expression was significantly correlated with vascular invasion (P = 0.0018), lymphatic permeation (P = 0.049), T factor (P = 0.0024), and pathological stage (P = 0.0003). High OCIAD2 expression was significantly associated with poorer overall survival (OS) (n = 191, P = 0.0325). In peripheral-type lung adenocarcinomas (n = 161), high OCIAD2 expression was significantly associated with both poorer OS (P = 0.0214) and poorer disease-free survival (P = 0.0496). Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) showed weaker OCIAD2 expression than invasive adenocarcinoma. Among small adenocarcinomas measuring 2 cm or less in greatest dimension classified according to the Noguchi's classification (n = 79), invasive adenocarcinomas showed significantly higher OCIAD2 expression than non-invasive adenocarcinomas (P = 0.0007). Interestingly, OCIAD2 was expressed heterogeneously even within a tumor, and its expression was higher in areas of invasion than in areas of in situ spread. Our results suggest that OCIAD2 could be a useful prognostic biomarker of lung adenocarcinoma.