A Prospectively Validated Nomogram for Predicting the Risk of PHQ-9 Score ≥15 in Patients With Erectile Dysfunction: A Multi-Center Study.
A Prospectively Validated Nomogram for Predicting the Risk of PHQ-9 Score ≥15 in Patients With Erectile Dysfunction: A Multi-Center Study.
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DOI：
10.3389/fpubh.2022.836898
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发表时间：
2022
影响因子：
5.2
通讯作者：
Yuan, Jianlin
中科院分区：
文献类型：
--
作者：
Zheng, Yu;Gao, Ming;Hou, Guangdong;Hou, Niuniu;Feng, Xiao;Jannini, Tommaso B.;Wei, Di;Zheng, Wanxiang;Zhang, Lei;Dun, Xinlong;Zhang, Geng;Wang, Fuli;Meng, Ping;Jannini, Emmanuele A.;Yuan, Jianlin
虽然勃起功能障碍（艾德）通常与抑郁症同时发生，但并非所有艾德患者都患有重度抑郁症（MD），PHQ-9评分≥15表示MD。由于PHQ-9问卷中包含“我认为我是一个失败者”、“我想自杀”等短语，使用PHQ-9后，艾德患者的心理负担可能不可避免地增加，进而影响艾德的治疗效果。因此，我们建议开发一个列线图来预测这些患者PHQ-9评分≥15的个体风险。对2017年1月至2020年5月在西京医院和西北妇女儿童医院确诊的1,142例艾德患者的资料进行分析。采用最小绝对收缩和选择算子回归筛选PHQ-9评分≥15个相关危险因素，并进行多因素Logistic回归分析验证这些因素，构建诺模图。使用训练队列和包含877例前瞻性入组患者的独立队列来证明列线图的有效性。IIEF-5评分、PEDT评分、躯体疼痛评分、尿频和无休止排尿感是PHQ-9评分≥15分的独立影响因素。由这5个因素构建的列线图在内部和外部验证中显示出良好的校准性和区分性，预测准确率分别为0.757和0.722。列线图在训练队列中的敏感性和特异性分别为0.86和0.52。此外，诺模图在验证队列中的敏感性和特异性分别为0.73和0.62。此外，根据诺模图，样本被分为低风险和高风险组。本研究建立了预测ED患者PHQ-9评分≥15的个体风险的列线图，认为该列线图可用于早期预防MD低风险患者不必要地填写问卷。
Although erectile dysfunction (ED) often occurs simultaneously with depression, not all patients with ED suffer major depression (MD), with a PHQ-9 score ≥15 indicating MD. Because the PHQ-9 questionnaire includes phrases such as “I think I am a loser” and “I want to commit suicide,” the psychological burdens of ED patients are likely to increase inevitably after using the PHQ-9, which, in turn, may affect ED therapeutic effects. Accordingly, we endeavored to develop a nomogram to predict individual risk of PHQ-9 score ≥15 in these patients. The data of 1,142 patients with ED diagnosed in Xijing Hospital and Northwest Women and Children's Hospital from January 2017 to May 2020 were analyzed. While the Least Absolute Shrinkage and Selection Operator regression was employed to screen PHQ-9 score ≥15 related risk factors, multivariate logistic regression analysis was performed to verify these factors and construct the nomogram. The training cohort and an independent cohort that comprised 877 prospectively enrolled patients were used to demonstrate the efficacy of the nomogram. The IIEF-5 score, PEDT score, physical pain score, frequent urination, and feeling of endless urination were found to be independent factors of PHQ-9 score ≥15 in patients with ED. The nomogram developed by these five factors showed good calibration and discrimination in internal and external validation, with a predictive accuracy of 0.757 and 0.722, respectively. The sensitivity and specificity of the nomogram in the training cohort were 0.86 and 0.52, respectively. Besides, the sensitivity and specificity of the nomogram in the validation cohort were 0.73 and 0.62, respectively. Moreover, based on the nomogram, the sample was divided into low-risk and high-risk groups. This study established a nomogram to predict individual risk of PHQ-9 score ≥15 in patients with ED. It is deemed that the nomogram may be employed initially to avoid those with a low risk of MD completing questionnaires unnecessarily.
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影响因子：
3.5
作者：
Corona, Giovanni;Rastrelli, Giulia;Maggi, Mario
通讯作者：
Maggi, Mario
DOI：
10.3233/jrs-210023
发表时间：
2022
期刊：
The International journal of risk & safety in medicine
影响因子：
--
作者：
Healy D;Bahrick A;Bak M;Barbato A;Calabrò RS;Chubak BM;Cosci F;Csoka AB;D'Avanzo B;Diviccaro S;Giatti S;Goldstein I;Graf H;Hellstrom WJG;Irwig MS;Jannini EA;Janssen PKC;Khera M;Kumar MT;Le Noury J;Lew-Starowicz M;Linden DEJ;Lüning C;Mangin D;Melcangi RC;Rodríguez OWMAAS;Panicker JN;Patacchini A;Pearlman AM;Pukall CF;Raj S;Reisman Y;Rubin RS;Schreiber R;Shipko S;Vašečková B;Waraich A
通讯作者：
Waraich A
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影响因子：
16.9
作者：
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影响因子：
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作者：
Rajkumar, Ravi Philip;Kumaran, Arun Kumar
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影响因子：
3.5
作者：
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