Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans.
Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans.
复制标题
糖原消耗引起的乳酸减少会减弱运动人类的反射反应。
DOI：
10.1152/ajpheart.1992.263.5.h1499
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Moore,RL
中科院分区：
文献类型：
--
作者：
Sinoway,LI;Wroblewski,KJ;Prophet,SA;Ettinger,SM;Gray,KS;Whisler,SK;Miller,G;Moore,RL
Post leg exercise circulatory arrest (PLE-CA) raises blood pressure (BP) and reduces peak forearm vascular conductance (C). This reflex is evoked by activation of muscle afferents that are often sensitive to lactic acid. We tested the hypothesis that lactic acid reductions induced by muscle glycogen depletion would attenuate the lower-limb metaboreceptor-mediated pressor and forearm vasoconstrictor responses. Eleven subjects had C measured (plethysmography) during post leg exercise circulatory arrest (PLE-CA) (supine bicycle exercise for 9 min, 10 s at 75% VO2max before and after undergoing a glycogen-depletion paradigm (24-h fast followed by 10 min of supine leg exercise at 75% VO2max). In six subjects with lower lactate values, C during PLE-CA was higher after glycogen depletion (0.39 +/- 0.05 vs. 0.21 +/- 0.01 ml.min-1.100 ml-1 x mmHg-1; P < 0.01) and BP was lower (113 +/- 6 vs. 128 +/- 6 mmHg, P < 0.01). In five subjects without attenuated lactate responses, C and BP during PLE-CA were not different. Muscle biopsies (n = 5) demonstrated that the paradigm lowered muscle glycogen concentrations. Thus glycogen depletion-induced reductions in muscle lactate are associated with reduced muscle metaboreceptor-mediated responses.
