Analysis of conditioned courtship in dusky-Andante rhythm mutants of Drosophila.
Analysis of conditioned courtship in dusky-Andante rhythm mutants of Drosophila.
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果蝇暗色行板节律突变体的条件求偶分析。
DOI：
10.1101/lm.2.2.49
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Hall,JC
中科院分区：
文献类型：
--
作者：
vanSwinderen,B;Hall,JC
先前的研究表明，学习和节奏之间存在遗传联系，部分原因是果蝇中的duskyAndante（dyAnd）突变破坏了这两种行为。dyAnd作为一种慢时钟变体被分离出来，据报道，它能使求爱抑制条件反射减少大约四倍。这些效应已经被重新检验过了。实验通过测试几个最近分离的dusky基因座突变的效应得到了支持，这些突变与最初在那里诱导的And等位基因一起沿着。重新检查也促使解剖学的关注，其中一些最近集中在Dy诱导的细胞大小的递减，但仅在翅形态。另一个解剖学问题涉及到一个神经元通路的发现，该通路似乎将昼夜节律起搏细胞与果蝇大脑中参与学习的结构连接起来。然而，在双盲实验中，研究人员发现，无论是起搏器减慢（类行板）dy突变还是其他不引起节律缺陷的突变，都不会产生低于正常的条件求偶。此外，在一个慢时钟dyAnd突变体的成年大脑中，没有轴突通路缺陷是很容易辨别的，推定的起搏神经元的大小似乎是正常的。
Genetic connections between learning and rhythmicity were suggested to have been established in a previous study, in part because the duskyAndante (dyAnd) mutation in Drosophila disrupted both behaviors. dyAnd, isolated as a slow-clock variant, was reported to cause an approximately fourfold decrement in courtship-suppression conditioning. These effects have been reexamined; the experiments were buttressed by testing the effects of several recently isolated mutations at the dusky locus, along with the original And Allele that had been induced there. The reexamination was also prompted by anatomical concerns, certain of which have recently focused on dy-induced decrements in cell size, but only in terms of wing morphology. Another anatomical issue involves the discovery of a neuronal pathway that seems to connect circadian pacemaker cells to a structure in the Drosophila brain that is involved in learning. In observer-blind experiments, however, it was found that neither pacemaker-slowing (Andante-like) dy mutations nor others that cause no rhythm defects produced subnormal conditioned courtship. Moreover, in the adult brain of a slow-clock dyAnd mutant, no axonal pathway defects were readily discernible and putative pacemaker neurons appeared to be normal in size.
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