Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
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DOI：
10.1136/medethics-2020-106501
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发表时间：
2020-12-01
影响因子：
4.1
通讯作者：
Eyal, Nir
中科院分区：
文献类型：
--
作者：
Steel, Robert;Buchak, Lara;Eyal, Nir
为了对抗严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的大流行，一些人建议通过控制人类感染（或“挑战”）试验加速SARS-CoV-2疫苗的开发。这些试验将涉及相对较少的年轻健康志愿者故意暴露于SARS-CoV-2。我们为这项提议辩护，反对有关COVID-19风险仍存在太多不确定性而无法负责任地进行此类试验的指控。
To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or 'challenge') trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.