Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation
Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation
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DOI：
10.1016/s0955-0674(98)80044-6
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Dano, K
中科院分区：
文献类型：
--
作者：
Johnsen, M;Lund, LR;Dano, K
对细胞外基质降解系统的分析已经使我们认识到，在癌症侵袭中，癌细胞和周围几种类型的非肿瘤性基质细胞之间通常存在至关重要的相互作用。同样，在正常组织重塑过程中，蛋白水解组分的合成通常分布在几种细胞类型之间，并且在同一组织中的肿瘤性和非肿瘤性过程之间存在很强的相似性。因此，组织重塑事件是研究癌症细胞外蛋白水解的极好模型。最近对转基因小鼠的分析更清楚地表明了这一点。
Analysis of extracellular matrix degradation systems has led to the insight that in cancer invasion there is often crucial interplay between cancer cells and several types of surrounding non-neoplastic stromal cells, Likewise, in normal tissue remodeling processes, the synthesis of proteolytic components is often distributed between several cell types, and there are strong similarities between neoplastic and nonneoplastic processes in the same tissue. Thus, tissue remodeling events are excellent models for studies of extracellular proteolysis in cancer. This has become even clearer by recent analyses of genetically modified mice.