Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)
Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)
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DOI：
10.1177/0300985820943535
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发表时间：
2020-07-14
影响因子：
2.4
通讯作者：
van der Poel, Wim H. M.
中科院分区：
文献类型：
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作者：
Molenaar, Robert Jan;Vreman, Sandra;van der Poel, Wim H. M.
COVID-19的病原体SARS-CoV-2导致荷兰4个水貂养殖场爆发呼吸道疾病，死亡率增加。最引人注目的尸检发现是急性间质性肺炎，几乎所有在疫情高峰期死亡的水貂都发现了这种疾病。急性肺泡损伤是一个一致的组织病理学发现水貂死于肺炎。通过检测咽拭子中的病毒RNA和通过免疫组织化学检测鼻甲、气管和肺中的病毒抗原来确认SARS-CoV-2感染。在临床上，疫情持续了约4周，但一些动物在临床症状消失后，咽拭子中的SARS-CoV-2聚合酶链反应仍呈阳性。这是首次报道水貂养殖场爆发的SARS-CoV-2的临床和病理特征。
SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction-positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.