Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.
Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels.
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DOI：
10.1186/s40101-017-0143-9
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发表时间：
2017-06-15
影响因子：
3.1
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Sato S;Koyamatsu J;Yamanashi H;Nagayoshi M;Kadota K;Kawashiri SY;Maeda T
尽管高密度脂蛋白-胆固醇（HDL）水平与心血管事件呈负相关，但也有报道称HDL与高血压呈正相关，高血压是一种已知的内皮损伤因子。由于HDL通过增加循环内皮祖细胞（cd34阳性细胞）的数量介导对血管内皮的重要保护作用，因此循环cd34阳性细胞的水平应影响HDL与高血压之间的关系。为了研究HDL和高血压之间与循环cd34阳性细胞水平的关系，我们对477名60-69岁的老年男性进行了横断面研究，他们参加了一般健康检查。研究发现，在循环cd34阳性细胞水平高的受试者中，HDL与高血压呈显著正相关，而在循环cd34阳性细胞水平低的受试者中，HDL与高血压无显著相关性。已知心血管危险因素校正后，HDL （13.8 mg/dL）每增加一个标准差（SD），高水平循环cd34阳性细胞受试者高血压的odds （ORs）和95%置信区间（CIs）为1.44(1.06,1.96)，低水平循环cd34阳性细胞受试者为0.87（0.63,1.19）。我们还揭示了HDL水平和cd34阳性细胞水平对高血压的显著相关性，这种相互作用对高血压的影响的完全调整p值为0.022。独立于已知的心血管危险因素，高密度脂蛋白被发现与高水平循环cd34阳性细胞的受试者高血压呈正相关，但与低水平循环cd34阳性细胞的受试者无关。
Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60–69 years who participated in general health checkup. HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022. Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.