Choline in the aging brain
Choline in the aging brain
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DOI：
10.1016/s0006-8993(02)03155-4
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发表时间：
2002-10-04
期刊：
影响因子：
2.9
通讯作者：
Degani, H
中科院分区：
文献类型：
--
作者：
Katz-Brull, R;Koudinov, AR;Degani, H
质子磁共振波谱已越来越多地用于脑研究，以监测非侵入性代谢物，如N-乙酰天冬氨酸（NAA），肌酸（Cr）和胆碱（Cho）。我们在这里提出的研究，这些代谢物的比例在大鼠脑中测量在体内和胆碱运输和脂质合成在大鼠脑切片，在体外的老化的影响。在体研究表明，老龄海马Cho/NAA和Cho/Cr比值升高，而Cr/NAA比值与成年海马相似。这三个比例在成年和老年大鼠的皮质中保持相似。体外研究表明，在老年皮层和老年海马的低亲和力胆碱摄取的活动增加，可能补偿的高亲和力摄取活动和胆碱扩散速率的下降。胆碱掺入磷脂表现出高和低的亲和力动力学，不改性老化。(C)2002 Elsevier Science B. V.保留所有权利。
Proton magnetic resonance spectroscopy has been increasingly utilized in brain research to monitor non-invasively metabolites such as N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho). We present here studies of the effect of aging on the ratios of these metabolites measured in the rat brain in vivo and on choline transport and lipid synthesis in rat brain slices, in vitro. The in vivo studies indicated that the ratios of Cho/NAA and Cho/Cr increased in the aged hippocampus, whereas the ratio of Cr/NAA was similar in the aged and adult hippocampus. These three ratios remained similar in the cortex of adult and aged rats. The in vitro studies revealed that in the aged cortex and the aged hippocampus the activity of the low-affinity choline uptake increased, possibly compensating for a decrease in the high-affinity uptake activity and the rate of choline diffusion. The incorporation of choline into phospholipids exhibited high and low affinity kinetics which were not modified by aging. (C) 2002 Elsevier Science B.V. All rights reserved.