Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation
Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation
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DOI：
10.1016/s0944-7113(99)80031-2
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发表时间：
1999-03-01
期刊：
影响因子：
7.9
通讯作者：
Wagner, H
中科院分区：
文献类型：
--
作者：
Amroyan, E;Gabrielian, E;Wagner, H
穿心莲内酯是中药穿心莲的活性成分，在斯堪的纳维亚用于预防和治疗普通感冒，被称为抗炎、抗病毒、抗血栓、降血压和抗动脉粥样硬化药物，研究了其对类二十烷酸生物合成和血小板活化因子（PAF）的影响。而在离体人多形核白细胞（PMNL）中未发现对生物合成的影响，这表明穿心莲内酯抑制paf诱导的人血小板聚集呈剂量依赖性（IC50与5 μ M相似）。这些结果表明，穿心莲内酯具有不同于非甾体抗炎药（NSAID）的作用机制，并且很可能与穿心莲的心血管和抗血栓活性有关。
Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF). Whereas in isolated human polymorphonuclear leukocytes (PMNL) no influence on the biosynthesis was found, it could be shown that andrographolide inhibits PAF-induced human blood platelet aggregation in a dose dependent manner (IC50 similar to 5 mu M). These results indicate that andrographolide has a mechanism of action different from that of non-steroidal antiinflammatory drugs (NSAID) and most likely associated with the cardiovascular and antithrombotic activity described of Andrographis paniculata.