Association between oxidative stress and bone mineral density
Association between oxidative stress and bone mineral density
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DOI：
10.1006/bbrc.2001.5747
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发表时间：
2001-10-19
影响因子：
3.1
通讯作者：
Melhus, H
中科院分区：
文献类型：
--
作者：
Basu, S;Michaëlsson, K;Melhus, H
自由基已被证明参与骨吸收在体外和啮齿动物。我们从一项基于人群的研究中研究了氧化应激对48名女性和53名男性骨密度的影响。在尿样本中测量8-iso-PGF(2 α)（一种主要的f -2-异前列腺素和氧化应激的生物标志物）和对照15-酮-二氢pgf (2 α)（炎症反应的生物标志物）的水平，并检查它们与BAM和定量超声（QUS）测量的关系。在多元线性回归分析中，8-iso-PGF（2 α）水平与BNM和QUS呈负相关。相反，没有发现15-酮-二氢pgf （2 α）的关联。我们的研究结果建立了氧化应激增加和骨密度降低之间的生化联系，并为进一步研究促抗氧化剂和抗氧化剂在骨质疏松症中的作用提供了依据。(C) 2001学术出版社。
Free radicals have been shown to be involved in bone resorption in vitro and in rodents. We studied the effect of oxidative stress on bone mineral density (BMD) in 48 women and 53 men from a population-based study. The levels of 8-iso-PGF(2 alpha) (a major F-2-isoprostane and a biomarker of oxidative stress) and a control, 15-keto-dihydro-PGF(2 alpha) (a biomarker of inflammatory response), were measured in urinary samples and their association with BAM and quantitative ultrasound (QUS) measurements were examined. In multivariate linear regression analyses, 8-iso-PGF(2 alpha) levels were negatively associated with both BNM and QUS. In contrast, no association was found for 15-keto-dihydro-PGF(2 alpha). Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis. (C) 2001 Academic Press.