Oculomotor control in children with fetal alcohol spectrum disorders assessed using a mobile eye-tracking laboratory
Oculomotor control in children with fetal alcohol spectrum disorders assessed using a mobile eye-tracking laboratory
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DOI：
10.1111/j.1460-9568.2009.06668.x
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发表时间：
2009-03-01
影响因子：
3.4
通讯作者：
Reynolds, J. N.
中科院分区：
文献类型：
--
作者：
Green, C. R.;Mihic, A. M.;Reynolds, J. N.
产前暴露于酒精可导致一系列不良发育结果，统称为胎儿酒精谱系障碍（FASD）。本研究评估了FASD儿童的感觉、运动和认知处理缺陷，这些缺陷可以通过眼动测试来识别。我们的研究组由89名8-15岁的儿童组成，诊断为FASD谱系[即胎儿酒精综合征（FAS），部分胎儿酒精综合征（pFAS）和酒精相关神经发育障碍（ARND）]，92名对照组。受试者看向（正面扫视）或远离（反扫视）出现在电脑显示器上的周边目标，眼球运动记录与移动的，基于视频的眼动仪。我们假设：（i）在三个诊断亚组中，眼动控制缺陷的程度存在差异;（ii）FASD儿童在眼动控制方面表现出发育迟缓。患有FASD的儿童的扫视反应时间（SRT）增加，SRT的受试者内变异性增加，并且在正视和反正视任务中的方向错误增加。虽然发展与任务的改善有关，但FASD儿童在任何测试年龄都未能达到年龄匹配的控制水平。此外，ARND的儿童有更快的SRT和更少的方向错误，在antisaccade任务比pFAS或FAS的儿童，虽然所有的亚组与对照组不同。我们的研究结果表明，眼动追踪可以作为一个客观的衡量脑损伤FASD，揭示行为缺陷，在所有三个诊断亚组独立的面部畸形。
Prenatal exposure to alcohol can result in a spectrum of adverse developmental outcomes, collectively termed fetal alcohol spectrum disorders (FASDs). This study evaluated deficits in sensory, motor and cognitive processing in children with FASD that can be identified using eye movement testing. Our study group was composed of 89 children aged 8-15 years with a diagnosis within the FASD spectrum [i.e. fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS), and alcohol-related neurodevelopmental disorder (ARND)], and 92 controls. Subjects looked either towards (prosaccade) or away from (antisaccade) a peripheral target that appeared on a computer monitor, and eye movements were recorded with a mobile, video-based eye tracker. We hypothesized that: (i) differences in the magnitude of deficits in eye movement control exist across the three diagnostic subgroups; and (ii) children with FASD display a developmental delay in oculomotor control. Children with FASD had increased saccadic reaction times (SRTs), increased intra-subject variability in SRTs, and increased direction errors in both the prosaccade and antisaccade tasks. Although development was associated with improvements across tasks, children with FASD failed to achieve age-matched control levels of performance at any of the ages tested. Moreover, children with ARND had faster SRTs and made fewer direction errors in the antisaccade task than children with pFAS or FAS, although all subgroups were different from controls. Our results demonstrate that eye tracking can be used as an objective measure of brain injury in FASD, revealing behavioral deficits in all three diagnostic subgroups independent of facial dysmorphology.