The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects.
The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects.
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DOI：
10.1016/j.jtemb.2012.03.012
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Costa M
中科院分区：
文献类型：
--
作者：
Arita A;Shamy MY;Chervona Y;Clancy HA;Sun H;Hall MN;Qu Q;Gamble MV;Costa M
镍和砷化合物致癌的确切机制尚不完全清楚。近年来，表观遗传机制的改变被认为与这两种金属化合物的致癌有关。在体外，暴露于镍或砷会导致DNA甲基化模式的改变，以及组蛋白尾巴翻译后修饰水平的变化。据报道，暴露在砷中的人类受试者DNA甲基化模式发生了变化。在这里，我们回顾了最近关于职业性镍暴露受试者和饮用水中砷暴露受试者外周血单个核细胞(PBMC)组蛋白翻译后修饰水平变化的最新报道。职业性接触镍与H3K4me3增加和H3K9me2减少有关。在暴露于砷的受试者中，发现H3K9me2的全球增加和H3K9ac的减少。此外，与女性相比，暴露于砷会导致男性组蛋白修饰的一些相反的变化。这两项研究的结果表明，暴露于镍或砷化合物，可能还有其他致癌金属化合物，可以诱导外周血单个核细胞翻译后组蛋白修饰的整体水平发生变化。
The precise mechanisms for the carcinogenesis of nickel and arsenic compounds are not completely understood. In recent years, alterations of epigenetic mechanisms have been implicated in the carcinogenesis of these two metal compounds. In vitro exposure to nickel or arsenic induces changes in both DNA methylation patterns, as well as, in the levels of posttranslational modifications of histone tails. Changes in DNA methylation patterns have been reported in human subjects exposed to arsenic. Here we review our recent reports on the alterations in global levels of posttranslational histone modifications in peripheral blood mononuclear cells (PBMCs) of subjects with occupational exposure to nickel and subjects exposed to arsenic in their drinking water. Occupational exposure to nickel was associated with an increase in H3K4me3 and decrease in H3K9me2. A global increase in H3K9me2 and decrease in H3K9ac was found in subjects exposed to arsenic. Additionally, exposure to arsenic resulted in opposite changes in a number of histone modifications in males compared to females. The results of these two studies suggest that exposure to nickel or arsenic compounds, and possibly other carcinogenic metal compounds, can induce changes in global levels of posttranslational histone modifications in peripheral blood mononuclear cells.
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DOI：
10.1073/pnas.94.20.10907
发表时间：
1997-09-30
影响因子：
11.1
作者：
Zhao, CQ;Young, MR;Waalkes, MP
通讯作者：
Waalkes, MP
影响因子：
3.8
作者：
Reichard JF;Puga A
通讯作者：
Puga A
影响因子：
10.4
作者：
Arita A;Niu J;Qu Q;Zhao N;Ruan Y;Nadas A;Chervona Y;Wu F;Sun H;Hayes RB;Costa M
通讯作者：
Costa M
影响因子：
3.8
作者：
Zhou X;Li Q;Arita A;Sun H;Costa M
通讯作者：
Costa M
影响因子：
4.7
作者：
Zhou, Xue;Sun, Hong;Costa, Max
通讯作者：
Costa, Max