Effects of artificial and natural baroreceptor stimulation on nociceptive responding and pain
Effects of artificial and natural baroreceptor stimulation on nociceptive responding and pain
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DOI：
10.1111/1469-8986.00076
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发表时间：
2003-09-01
期刊：
影响因子：
3.7
通讯作者：
Martin, U
中科院分区：
文献类型：
--
作者：
Edwards, L;McIntyre, D;Martin, U
动脉压力感受性反射可能介导高血压性痛觉减退。颈动脉压力感受器可以通过颈部抽吸人工刺激，并通过压迫抑制。本文观察了25例正常血压成人颈部短暂吸引和压迫对伤害性反应和疼痛的影响。在收缩期或间歇期以阈强度电刺激腓肠神经，并结合颈部吸引、颈部压迫或无压力。伤害性反应的指标是在股二头肌引起的肌电图活动。参与者对腓肠神经刺激的强度进行评分。虽然人工压力感受器刺激（抽吸）不影响伤害性反应，压力感受器抑制（压缩）降低疼痛等级。与此相反，自然压力感受器刺激收缩期减少伤害性反应相比，阿曲洛尔，但不影响疼痛评级。这些数据提供了部分支持压力反射调制疼痛。
The arterial baroreflex may mediate hypertensive hypoalgesia. Carotid baroreceptors can be artificially stimulated by neck Suction and inhibited by compression. Effects of brief neck suction and compression on nociceptive responding and pain were studied in 25 normotensive adults. The sural nerve was electrocutaneously stimulated at threshold intensity during systole or diastole combined with neck suction, neck compression, or no pressure. Nociceptive responding was indexed by electromyographic activity elicited in the biceps femoris. Participants rated the intensity of sural stimulation. Although artificial baroreceptor stimulation (suction) did not affect nociceptive responding, baroreceptor inhibition (compression) reduced pain ratings. In contrast, natural baroreceptor stimulation during systole reduced nociceptive responding compared to diastole, but did not affect pain ratings. The data provide partial support for baroreflex modulation of pain.