Schistosomiasis protects against multiple sclerosis
Schistosomiasis protects against multiple sclerosis
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DOI：
10.1590/s0074-02762004000900006
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发表时间：
2004-08-01
期刊：
影响因子：
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通讯作者：
Bäckström, B Thomas
中科院分区：
文献类型：
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作者：
La Flamme, Anne Camille;Canagasabey, Kanishka;Bäckström, B Thomas
在世界范围内，血吸虫病和多发性硬化症（MS）的发病率是相互排斥的，这表明血吸虫病可能对免疫介导的多发性硬化症（MS）的诱导提供保护。最近的研究使用小鼠多发性硬化症模型，实验性自身免疫性脑脊髓炎，支持慢性曼氏血吸虫感染直接抑制多发性硬化症的发病。在髓鞘少突胶质细胞糖蛋白免疫的感染小鼠中，自身反应性Th1而非Th2反应发生，尽管水平降低，表明自身反应性T细胞的诱导不会被消除，也不会发生表型改变。与未感染的免疫小鼠相比，曼氏梭菌感染的免疫小鼠中炎症细胞，特别是巨噬细胞的中枢神经系统浸润明显减少。由于活化的巨噬细胞对临床疾病的诱导至关重要，这些发现支持了巨噬细胞活化的差异可能有助于减少血吸虫病期间实验性自身免疫性脑脊髓炎的发病率和延迟进展的假设。
The incidences of schistosomiasis and multiple sclerosis (MS) are mutually exclusive worldwide suggesting that schistosomiasis may offer protection against the induction of the immune-mediated disease, MS. Recent studies using the mouse model of MS, experimental autoimmune encephalomyelitis, support a direct suppression of the onset of MS by chronic Schistosoma mansoni infection. Self-reactive Th1 but not Th2 responses develop in infected mice immunized with myelin oligodendrocyte glycoprotein albeit at reduced levels indicating that the induction of auto-reactive T cells is not abolished nor phenotypically altered. CNS infiltration by inflammatory cells, particularly macrophages, is significantly reduced in S. mansoni-infected, immunized mice compared to uninfected, immunized mice. Because activated macrophages are crucial to the induction of clinical disease, these findings support the hypothesis that differences in macrophage activation may contribute to the reduced incidence and delayed progression of experimental autoimmune encephalomyelitis during schistosomiasis.