UV-MEDIATED CATARACTOGENESIS - A RADICAL PERSPECTIVE
UV-MEDIATED CATARACTOGENESIS - A RADICAL PERSPECTIVE
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DOI：
10.1007/bf01203677
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发表时间：
1994-01-01
影响因子：
1.4
通讯作者：
EATON, JW
中科院分区：
文献类型：
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作者：
EATON, JW
一些流行病学和实验研究间接支持太阳紫外线辐射可能是白内障形成的想法。然而，这种白内障发生中可能涉及的物理和细胞过程并不清楚。由于含氧有机物的UV照射的主要结果是产生活性氧物质，因此氧化剂的参与被怀疑是重要的。然而，由于透镜通常可存在于低氧或甚至缺氧环境中，因此用于此类反应的氧的可用性程度目前是未知的。因此，也可能是通过假定的紫外线损伤的透镜可能最终导致白内障的机制。除了可能对透镜上皮细胞造成快速和直接的致命损伤外，还可能对晶状体DNA和蛋白质造成累积损伤。此外，紫外线辐射有可能通过光解破坏光敏营养素，并通过与含铁化合物的相互作用产生有害的氧化剂。鉴于自然界可能已经为透镜提供了实质性的保护装置，以抵御紫外线的破坏性影响，太阳辐射是否有助于白内障的形成，以及如果是这样，通过什么机制，仍然是一个悬而未决的问题。
A number of epidemiologic and experimental studies indirectly support the idea that solar ultraviolet radiation may be cataractogenic. However, the physical and cellular processes which might be involved in such cataractogenesis are by no means clear. Because a major consequence of the UV irradiation of oxygenated organic matter is the production of activated oxygen species, the involvement of oxidants has been suspected to be of importance. However, because the lens may normally exist in an hypoxic or even anoxic environment, the extent of availability of oxygen for such reactions is presently unknown. So also are the possible mechanisms through which putative UV damage of the lens might eventuate in cataract. In addition to possible rapid and direct lethal damage to lens epithelium, possible cumulative damage to both lenticular DNA and proteins may occur. Furthermore, UV radiation has the potential to photolytically destroy light-sensitive nutrients and to generate damaging oxidants through interaction with ferruginous compounds. Given that Nature has probably provided the lens with substantial protective devices to ward off damaging effects of UV light, it is still an open question as to whether solar radiation contributes to cataract formation and, if so, by what mechanisms.