Diurnal variations in the levels of plasma and urinary androgens.
Diurnal variations in the levels of plasma and urinary androgens.
复制标题
血浆和尿雄激素水平的昼夜变化。
DOI：
--
复制
发表时间：
1971
影响因子：
5.8
通讯作者：
S. Ito
中科院分区：
文献类型：
--
作者：
M. Okamoto;C. Setaishi;K. Nakagawa;Y. Horiuchi;K. Moriya;S. Ito
对12名正常男性受试者连续6个4小时测定尿中睾酮、表甾酮3和17-酮类固醇（17-KS）水平。测定5例受试者血浆黄体生成素（LH）、睾酮和皮质类固醇（CS）、尿17-羟基皮质类固醇（17-OHCS）水平，并与尿睾酮、表甾酮和17-KS水平进行比较。血浆CS和睾酮、尿17-KS、17-OHCS、睾酮和表睾酮均有显著变化。然而，血浆睾酮、尿睾酮和表睾酮的日变化幅度远小于血浆CS、尿17-KS和17-OHCS。在5名受试者中，有2名受试者的血浆LH浓度在白天发生了很大的变化，而在其他3名受试者中没有观察到变化。这些数据不能证明血浆睾酮的昼夜变化是LH水平变化的结果。一个……
ABSTRACT In 12 normal male subjects the urinary levels of testosterone, epitestosterone3 and 17-ketosteroids (17-KS) were determined for 6 consecutive 4-hr periods. In 5 of the subjects the levels of plasma luteinizing hormone (LH), testosterone and corticosteroids (CS) and urinary 17-hydroxycorticosteroids (17-OHCS) were also determined to compare with those of urinary testosterone, epitestosterone and 17-KS. Significant variations of plasma CS and testosterone, and urinary 17-KS, 17-OHCS, testosterone and epitestosterone were found. However, the magnitudes of the diurnal variations of plasma testosterone, and urinary testosterone and epitestosterone were much smaller than those observed for plasma CS and urinary 17-KS and 17-OHCS. In two of the 5 subjects there was a large change in the concentration of plasma LH during the day, whereas no change was observed in 3 other subjects. These data do not permit the conclusion that a diurnal variation of plasma testosterone is a result of changing LH levels. A ...