Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage
Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage
复制标题
DOI：
10.1021/acs.nanolett.0c00755
复制
发表时间：
2020-05-13
期刊：
影响因子：
10.8
通讯作者：
Keyser, Ulrich F.
中科院分区：
文献类型：
--
作者：
Chen, Kaikai;Zhu, Jinbo;Keyser, Ulrich F.
纳米孔是用于对包括DNA在内的纳米级分子进行无标记传感的强大单分子工具，可用于构建设计的纳米结构和进行计算。在此，基于DNA纳米技术和纳米孔传感引入了DNA硬盘（DNA - HDs）作为一种可重写的分子存储系统，允许在DNA可变的三维结构中存储、操作和读取数据。通过在长双链DNA上采用可控的分子附着和去除，与先前的分子存储系统相比，数据的写入和擦除得到了显著改善。利用纳米孔在毫秒时间尺度上检测单分子来实现数据读取。DNA - HD还确保了数据的安全存储，只有提供正确的物理分子密钥后才能读取数据。我们的方法实现了易于写入和读取、可重写以及安全的数据存储，朝着分子数据存储和计算的有前景的微型集成迈进。
Nanopores are powerful single-molecule tools for label-tree sensing of nanoscale molecules including DNA that can be used for building designed nanostructures and performing computations. Here, DNA hard drives (DNA-HDs) are introduced based on DNA nanotechnology and nanopore sensing as a rewritable molecular memory system, allowing for storing, operating, and reading data in the changeable three-dimensional structure of DNA. Writing and erasing data are significantly improved compared to previous molecular storage systems by employing controllable attachment and removal of molecules on a long double-stranded DNA. Data reading is achieved by detecting the single molecules at the millisecond time scale using nanopores. The DNA-HD also ensures secure data storage where the data can only be read after providing the correct physical molecular keys. Our approach allows for easy-writing and easy-reading, rewritable, and secure data storage toward a promising miniature scale integration for molecular data storage and computation.