The effect of highly active antiretroviral treatment on viral load and antiretroviral drug levels in breast milk
The effect of highly active antiretroviral treatment on viral load and antiretroviral drug levels in breast milk
复制标题
DOI：
10.1097/01.aids.0000188428.33280.41
复制
发表时间：
2005-11-04
期刊：
影响因子：
3.8
通讯作者：
Fransen, K
中科院分区：
文献类型：
--
作者：
Colebunders, R;Hodossy, B;Fransen, K
对九名接受高效抗逆转录病毒疗法（HAART）的母亲和一名在分娩期间仅接受齐多夫定治疗的母亲的血浆和母乳中的病毒载量和药物水平进行了测量。在所有接受HAART治疗的妇女中，分娩后血浆和母乳中的病毒载量均低于400拷贝/毫升。与血浆浓度相比，奈韦拉平的母乳浓度为68%至90%，奈非那韦为6%至24%，茚地那韦为90%至540%。
Viral load and drug levels were measured in the plasma and breast milk of nine mothers treated with highly active antiretroviral therapy (HAART) and one woman treated only with zidovudine during delivery. In all HAART-treated women after delivery the viral load was less than 400 copies/ml in plasma and breast milk. Compared with the plasma concentration, the breast milk concentration was between 68 and 90%, for nevirapine, 6 and 24% for nelfinavir and 90 and 540%, for indinavir.