Automatic and intrinsic auditory "what" and "where" processing in humans revealed by electrical neuroimaging
Automatic and intrinsic auditory "what" and "where" processing in humans revealed by electrical neuroimaging
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DOI：
10.1093/cercor/bhj119
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发表时间：
2007-01-01
期刊：
影响因子：
3.7
通讯作者：
Murray, Micah M.
中科院分区：
文献类型：
--
作者：
De Santis, Laura;Clarke, Stephanie;Murray, Micah M.
听觉系统包括两条平行的功能通路——一条处理声音的身份，另一条处理声音的空间属性（所谓的“什么”和“在哪里”通路）。我们研究了听觉“什么”和“在哪里”通路的时空机制，以及它们是否自动参与对相同刺激的空间和音高信息的差异处理。听觉诱发电位的神经电成像（即波形、场强、地形和源估计的统计分析）应用于被动的“古怪”范式，包括2种不同的试验块。在“什么”块上，带通滤波噪声的音高不同，与感知到的位置无关。在“where”块上，相同的刺激在感知位置上的变化与音调无关。从刺激后100 ms开始，不同条件下的电场形貌显著不同，表明不同的颅内发电机自动募集。分布式线性反解和统计分析显示，在这两种情况下，双侧颞上皮层和前额叶皮层的激活是常见的，而在“在哪里”的情况下，右侧颞顶叶皮层的区域是选择性的。这些发现支持了听觉信息的自动和内在并行处理模型，例如空间和音高特征的分离处理可能是听觉功能的组织原则。
The auditory system includes 2 parallel functional pathways-one for treating sounds' identities and another for their spatial attributes (so-called "what" and "where" pathways). We examined the spatio-temporal mechanisms along auditory "what" and "where" pathways and whether they are automatically engaged in differentially processing spatial and pitch information of identical stimuli. Electrical neuroimaging of auditory evoked potentials (i.e., statistical analyses of waveforms, field strength, topographies, and source estimations) was applied to a passive "oddball" paradigm comprising 2 varieties of blocks of trials. On "what" blocks, band-pass-filtered noises varied in pitch, independently of perceived location. On "where" blocks, the identical stimuli varied in perceived location independently of pitch. Beginning 100 ms poststimulus, the electric field topography significantly differed between conditions, indicative of the automatic recruitment of distinct intracranial generators. A distributed linear inverse solution and statistical analysis thereof revealed activations within superior temporal cortex and prefrontal cortex bilaterally that were common for both conditions, as well as regions within the right temporoparietal cortices that were selective for the "where" condition. These findings support models of automatic and intrinsic parallel processing of auditory information, such that segregated processing of spatial and pitch features may be an organizing principle of auditory function.