Prevention of noise- and drug-induced hearing loss with D-methionine
Prevention of noise- and drug-induced hearing loss with D-methionine
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DOI：
10.1016/j.heares.2006.11.012
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发表时间：
2007-04-01
期刊：
影响因子：
2.8
通讯作者：
Hughes, Larry F.
中科院分区：
文献类型：
--
作者：
Campbell, Kathleen C. M.;Meech, Robert P.;Hughes, Larry F.
目前正在研究多种耳保护剂。在动物研究中已发现各种类型的药物可以预防由顺铂、卡铂、氨基糖苷类或噪音暴露引起的听力损失。十多年来，我们一直在研究 D-蛋氨酸 (D-met) 作为耳保护剂。我们实验室和世界各地其他实验室的研究记录了 D-met 在多种物种中的耳保护作用，可抵抗各种耳毒性损伤，包括顺铂、卡铂、氨基糖苷类和噪音引起的听阈升高和耳蜗毛细胞损失。对于顺铂引起的耳毒性，对血管纹的保护也已被记录。此外，D-met 具有出色的安全性。 D-Met 可充当直接和间接抗氧化剂。在本报告中，我们提供了三项实验的结果，扩展了我们三个转化研究领域中 D-met 保护的发现：防止铂类化疗、氨基糖苷类药物和噪音引起的听力损失。这些实验证明，口服 D-Met 可以防止顺铂引起的耳毒性，D-Met 可以防止阿米卡星引起的耳毒性，以及当噪声暴露 1 小时后开始使用 D-Met 时，D-Met 可挽救永久性噪声引起的听力损失。这些研究证明了将保护剂从实验室转移到临床所需的一些动物实验。 (C) 2006 Elsevier B.V. 保留所有权利。
A number of otoprotective agents are currently being investigated. Various types of agents have been found in animal studies to protect against hearing loss induced by cisplatin, carboplatin, aminoglycosides, or noise exposure. For over a decade we have been investigating D-methionine (D-met) as an otoprotective agent. Studies in our laboratory and others around the world have documented D-met's otoprotective action, in a variety of species, against a variety of ototoxic insults including cisplatin-, carboplatin-, aminoglycoside- and noise-induced auditory threshold elevations and cochlear hair cell loss. For cisplatin-induced ototoxicity, protection of the stria vascularis has also been documented. Further D-met has an excellent safety profile. D-Met may act as both a direct and indirect antioxidant. In this report, we provide the results of three experiments, expanding findings in D-met protection in three of our translational research areas: protection from platinum based chemotherapy-, aminoglycoside- and noise-induced hearing loss. These experiments demonstrate oral D-Met protection against cisplatin-induced ototoxicity, D-Met protection against amikacin-induced ototoxicity, and D-met rescue from permanent noise-induced hearing loss when D-Met is initiated 1 h after noise exposure. These studies demonstrate some of the animal experiments needed as steps to translate a protective agent from bench to bedside. (C) 2006 Elsevier B.V. All rights reserved.