Bacterial Stress Responses during Host Infection.
Bacterial Stress Responses during Host Infection.
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DOI：
10.1016/j.chom.2016.07.009
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发表时间：
2016-08-10
影响因子：
30.3
通讯作者：
Vázquez-Torres A
中科院分区：
文献类型：
--
作者：
Fang FC;Frawley ER;Tapscott T;Vázquez-Torres A
病原菌在感染过程中必须经受住不同的宿主环境。环境信号，如pH、温度、营养稀缺性等，不仅在细菌内部触发对这些特定胁迫条件的适应性反应，而且还在适当的时间和地点指导毒力基因的表达。因此，对应激反应及其调控的认识对于了解细菌的发病机制是至关重要的。这篇综述讨论了宿主环境中的特定应激及其与发病机制的相关性，尤其是肠道病原体沙门氏菌。
Pathogenic bacteria must withstand diverse host environments during infection. Environmental signals, such as pH, temperature, nutrient scarcity, etc., not only trigger adaptive responses within bacteria to these specific stress conditions but also direct the expression of virulence genes at an appropriate time and place. An appreciation of stress responses and their regulation is therefore essential for an understanding of bacterial pathogenesis. This review considers specific stresses in the host environment and their relevance to pathogenesis, with a particular focus on the enteric pathogen Salmonella.