Maternal hypoxia during pregnancy delays the development of motor reflexes in newborn mice
Maternal hypoxia during pregnancy delays the development of motor reflexes in newborn mice
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DOI：
10.1159/000080708
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Huleihel, M
中科院分区：
文献类型：
--
作者：
Golan, H;Kashtutsky, I;Huleihel, M
产前缺氧缺血性脑损伤被认为会导致新生儿永久性的神经功能缺损。我们研究了妊娠期母亲缺氧导致子代脑损伤的可能性，以及通过口服MgSO4预防其发生的可能性。妊娠第17天的孕鼠经生理盐水或Mg预处理后，暴露于缺氧或空气中。暴露于缺氧环境中的新生小鼠在眼睑张开、毛发生长和牙齿长出等形态发生参数方面的发育速度更快。此外，缺氧延缓了运动反射的发展。Mg预处理补偿了缺氧引起的损伤，在某些情况下加速了这些功能的发展。综上所述，母体缺氧显著改变了新生小鼠的发育过程。在我们的研究中，Mg预处理对运动障碍有显著的预防作用。版权所有(C) 2004 S. Karger AG，巴塞尔。
Prenatal hypoxic-ischemic brain injury is believed to cause permanent neurological deficits in newborns. We investigated the possibility that maternal hypoxia during pregnancy leads to offspring brain damage and its prevention by i.p. administration of MgSO4. Pregnant mice at gestation day 17 were exposed to hypoxia or air following pretreatment with saline or Mg. Newborn mice to mothers exposed to hypoxia demonstrated faster development of morphogenic parameters such as eyelid opening, hair growth and teeth eruption. In addition, hypoxia delayed the development of motor reflexes. Pretreatment with Mg compensates for hypoxia-induced impairment and in some cases accelerates the development of these functions. In conclusion, maternal hypoxia significantly modifies the developmental process of newborn mice. In our study, pretreatment with Mg showed significant prophylactic action against motor impairments. Copyright (C) 2004 S. Karger AG, Basel.