A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury
A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury
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DOI：
10.1016/j.bbrc.2004.12.030
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发表时间：
2005-02-11
影响因子：
3.1
通讯作者：
Bhatia, M
中科院分区：
文献类型：
--
作者：
Lau, HY;Wong, FL;Bhatia, M
早期的研究表明，小鼠缺乏NK1受体或其配体。R物质可以预防急性胰腺炎和相关的肺损伤。本研究使用特异性受体拮抗剂CP-96345，研究了NK1受体阻断对急性胰腺炎及相关肺损伤的保护作用。通过腹腔注射小蛋白诱导小鼠急性胰腺炎。血浆、胰腺和肺部P物质水平呈剂量依赖性升高。通过血浆淀粉酶、胰腺和肺髓过氧化物酶活性的降低以及胰腺和肺损伤的组织学证据表明，用CP-96345治疗小鼠，无论是预防性还是治疗性，都可以防止急性胰腺炎和相关的肺损伤。肺微血管通透性也因CP-96345治疗而降低。这些结果指出了NK1受体在急性胰腺炎和相关肺损伤中的关键作用。(C) 2004爱思唯尔公司版权所有。
Earlier studies have shown that mice deficient in NK1 receptors or its ligand. substance R are protected against acute pancreatitis and associated lung injury. In the current study, the protective effect of NK1 receptor blockage against acute pancreatitis and associated lung injury was investigated, using a specific receptor antagonist, CP-96345. Acute pancreatitis was induced in mice by intraperitoneal (i.p.) injections of caerulein. Substance P levels in plasma, pancreas, and lungs were found to be elevated in a caerulein dose-dependent manner. Mice treated with CP-96345, either prophylactically, or therapeutically, were protected against acute pancreatitis and associated lung injury as evident by attenuation in plasma amylase, pancreatic and pulmonary myeloperoxidase activities, and histological evidence of pancreatic and pulmonary injuries. Pulmonary microvascular permeability was also reduced as a result of CP-96345 treatment. These results point to a key role of NK1 receptors in acute pancreatitis and associated lung injury. (C) 2004 Elsevier Inc. All rights reserved.