A Dengue virus serotype 4-dominated outbreak in central Vietnam, 2013
A Dengue virus serotype 4-dominated outbreak in central Vietnam, 2013
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2013 年越南中部爆发以 4 血清型为主的登革热病毒
DOI：
10.1016/j.jcv.2015.02.016
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发表时间：
2015
影响因子：
8.8
通讯作者：
Futoshi Hasebe.
中科院分区：
文献类型：
--
作者：
Yuki Takamatsu;Takeshi Nabeshima;Thuy Thi Thu Nguyen;Dinh Thi Dang;Ly Hoai Linh Pham;Hang Thi Pham;Lien Thi Nam Nguyen;Huong Ly Minh Phu;Thuy Thu Bui;Mai Thi Quynh Le;Kouichi Morita;Futoshi Hasebe.
登革热是由伊蚊传播的。登革病毒（DENV）7属于黄病毒科，黄病毒属1，并且具有4种血清型：8种DENV-1、DENV-2、DENV-3和DENV-4。在过去50年中，登革热的传播非常严重; 1970年之前，只有9个国家报告了登革热的传播，而2014年11月，已有100多个国家报告了登革热的传播（WHO，2014）。越南是一个登革热流行的国家，尤其是越南南部12个地方性登革热高发区2个。国家卫生和流行病学研究所的内部报告显示，越南南部每年的登革热病例比越南中部多约10倍（表S1）。15越南中部地区每年报告约1万例登革热病例。DENV-4在越南的每个地区都有发现，但自2001年以来，在这个国家还没有发现DENV-4-17为主的暴发。50岁以上18
Dengue diseases are transmitted by Aedes mosquitoes. Dengue virus (DENV) 7 belongs to the family Flaviviridae, genus Flaviviru s 1, and has 4 serotypes: 8 DENV-1, DENV-2, DENV-3, and DENV-4. Over the past 50 years dengue has 9 spread extraordinarily; only 9 countries were reported to have dengue 10 transmission prior to 1970, whereas over 100 countries have been reported in 11 2014 (WHO, 2014). Vietnam is a dengue endemic country, especially southern 12 Vietnam a hyper-endemic area 2. The in-house report of the National Institute of 13 Hygiene and Epidemiology (NIHE) showed that there were about ten-fold more 14 dengue cases in southern Vietnam than in central Vietnam annually (Table S1). 15 Yearly, about 10 thousand dengue cases have been reported from central 16 Vietnam. DENV-4 has been found in each area of Vietnam, but DENV-4-17 dominated outbreak has not been known in this country since 2001. Over 50 18