A Neurobehavioral Mechanism Linking Behaviorally Inhibited Temperament and Later Adolescent Social Anxiety
A Neurobehavioral Mechanism Linking Behaviorally Inhibited Temperament and Later Adolescent Social Anxiety
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DOI：
10.1016/j.jaac.2017.10.007
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发表时间：
2017-12-01
影响因子：
13.3
通讯作者：
Fox, Nathan A.
中科院分区：
文献类型：
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作者：
Buzzell, George A.;Troller-Renfree, Sonya V.;Fox, Nathan A.
目的：行为抑制（BI）是儿童早期发现的一种气质，是日后社交焦虑的一个危险因素。然而，社交焦虑发展的潜在机制仍不清楚。为了更好地了解社交焦虑的出现，纵向研究调查的变化在行为神经levels.Method：BI在实验室进行了评估，在2和3岁（N = 268）。孩子们在12岁时返回，并在两种情况下进行侧翼任务时记录脑电图：一次是相信他们被同龄人观察，另一次是没有被观察。这种方法将错误监控（错误相关的消极性）和行为（错误后反应时间减慢）的变化隔离为社会背景的函数。在12年，目前的社交焦虑症状和终身诊断的社交anxiets.Results：儿童BI前瞻性预测社会特定的错误相关的负性增加和社交焦虑症状，在青春期，这些症状直接相关的临床诊断。系列中介分析表明，社交错误相关的负性变化解释了BI与社交焦虑症状（n = 107）和诊断（n = 92）之间的关系，但仅限于社交背景也导致错误后反应时间延长（一种错误专注的测量）;该模型与广泛性焦虑没有显著相关。结果扩展了以前的工作，社会引起的变化，错误监测和错误的关注。这些措施可以索引BI与青少年社交焦虑症状和诊断的神经行为机制。这一机制可能与社会性焦虑的关系比与青少年期广泛性焦虑的关系更密切。
Objective: Behavioral inhibition (BI) is a temperament identified in early childhood that is a risk factor for later social anxiety. However, mechanisms underlying the development of social anxiety remain unclear. To better understand the emergence of social anxiety, longitudinal studies investigating changes at behavioral neural levels are needed.Method: BI was assessed in the laboratory at 2 and 3 years of age (N = 268). Children returned at 12 years, and an electroencephalogram was recorded while children performed a flanker task under 2 conditions: once while believing they were being observed by peers and once while not being observed. This methodology isolated changes in error monitoring (error-related negativity) and behavior (post-error reaction time slowing) as a function of social context. At 12 years, current social anxiety symptoms and lifetime diagnoses of social anxiety were obtained.Results: Childhood BI prospectively predicted social specific error-related negativity increases and social anxiety symptoms in adolescence; these symptoms directly related to clinical diagnoses. Serial mediation analysis showed that social error-related negativity changes explained relations between BI and social anxiety symptoms (n = 107) and diagnosis (n = 92), but only insofar as social context also led to increased post-error reaction time slowing (a measure of error preoccupation); this model was not significantly related to generalized anxiety.Conclusion: Results extend prior work on socially induced changes in error monitoring and error preoccupation. These measures could index a neurobehavioral mechanism linking BI to adolescent social anxiety symptoms and diagnosis. This mechanism could relate more strongly to social than to generalized anxiety in the periadolescent period.