DEPLETION OF CD4+ T-CELLS IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II DEFICIENT MICE
DEPLETION OF CD4+ T-CELLS IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II DEFICIENT MICE
复制标题
DOI：
10.1126/science.1910207
复制
发表时间：
1991-09-20
期刊：
影响因子：
56.9
通讯作者：
GLIMCHER, LH
中科院分区：
文献类型：
--
作者：
GRUSBY, MJ;JOHNSON, RS;GLIMCHER, LH
T细胞在胸腺中的成熟依赖于主要组织相容性复合体（MHC）分子的表达。通过破坏胚胎干细胞中的MHC II类A -β - b基因，培育出了缺乏II类分子细胞表面表达的小鼠。这些MHC II类缺陷小鼠的成熟CD4 + T细胞缺失，并且细胞介导的免疫反应存在缺陷。这些结果提供了遗传学证据，表明II类分子是成熟CD4 + T细胞的成熟和功能所必需的。
The maturation of T cells in the thymus is dependent on the expression of major histocompatibility complex (MHC) molecules. By disruption of the MHC class II A-beta-b gene in embryonic stem cells, mice were generated that lack cell surface expression of class II molecules. These MHC class II-deficient mice were depleted of mature CD4+ T cells and were deficient in cell-mediated immune responses. These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4+ T cells.