Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging.
Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging.
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DOI：
10.1002/hbm.23194
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发表时间：
2016-07
影响因子：
4.8
通讯作者：
Montague PR
中科院分区：
文献类型：
--
作者：
Hétu S;Luo Y;Saez I;D'Ardenne K;Lohrenz T;Montague PR
缰核是认知和情绪信号的中枢，这些信号被传递到中脑胺能中心，因此在目标导向行为中发挥着重要作用。尽管在啮齿动物和非人类灵长类动物中对缰核功能网络进行了很好的描述，但在人类中，缰核功能网络的特征仍然相对未知，部分原因是与大脑小结构的功能磁共振成像相关的方法学挑战。利用健康人体的高分辨率心电门控静息状态成像，并精确识别每个参与者的缰核，我们发现缰核在功能上与脑岛、副海马体、丘脑、中脑导水管周围灰质、脑桥、纹状体和黑质/腹侧被盖区复合体相连。此外，通过分别检查和比较左右缰核的功能图谱，我们首次提供了人类缰核功能连接不对称的证据。Hum Brain Mapp 37：2602-2615,2016。©2016作者人脑图谱，由Wiley期刊出版公司出版。
The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal‐oriented behaviors. Although it is well described in rodents and non‐human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high‐resolution cardiac‐gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602–2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.