Noninvasive Imaging of Cancer Immunotherapy.
Noninvasive Imaging of Cancer Immunotherapy.
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癌症免疫治疗的无创成像。
DOI：
10.7150/ntno.50860
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Rashidian M
中科院分区：
文献类型：
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作者：
Abousaway O;Rakhshandehroo T;Van den Abbeele AD;Kircher MF;Rashidian M
免疫疗法已经彻底改变了几种恶性肿瘤的治疗。尽管结果令人鼓舞，但许多患者对治疗没有反应。治疗效果的评价是具有挑战性的，预测治疗反应的可靠方法尚未获得。免疫治疗的结果来自治疗引起的肿瘤免疫景观的变化。因此，更好地了解浸润到肿瘤微环境中的免疫细胞的动力学可能从根本上帮助解决这一挑战，并提供评估甚至预测反应的工具。非侵入性成像方法，如PET和SPECT，提供全身图像，目前被视为最有前途的工具，可以揭示肿瘤中发生的事件，以应对治疗。这些工具可以提供可用于做出明智的临床决策的关键信息。在这里，我们回顾了非侵入性癌症成像领域的最新进展，重点是免疫治疗和核成像技术，并将讨论该领域如何向前迈进，以应对尚未解决的挑战。
Immunotherapy has revolutionized the treatment of several malignancies. Notwithstanding the encouraging results, many patients do not respond to treatments. Evaluation of the efficacy of treatments is challenging and robust methods to predict the response to treatment are not yet available. The outcome of immunotherapy results from changes that treatment evokes in the tumor immune landscape. Therefore, a better understanding of the dynamics of immune cells that infiltrate into the tumor microenvironment may fundamentally help in addressing this challenge and provide tools to assess or even predict the response. Noninvasive imaging approaches, such as PET and SPECT that provide whole-body images are currently seen as the most promising tools that can shed light on the events happening in tumors in response to treatment. Such tools can provide critical information that can be used to make informed clinical decisions. Here, we review recent developments in the field of noninvasive cancer imaging with a focus on immunotherapeutics and nuclear imaging technologies and will discuss how the field can move forward to address the challenges that remain unresolved.