PARATHYROID-HORMONE AND ELECTROLYTES DURING LONG-TERM TREATMENT WITH ALLOPURINOL AND THIAZIDE
PARATHYROID-HORMONE AND ELECTROLYTES DURING LONG-TERM TREATMENT WITH ALLOPURINOL AND THIAZIDE
复制标题
DOI：
10.1111/j.1464-410x.1987.tb04863.x
复制
发表时间：
1987-06-01
期刊：
影响因子：
--
通讯作者：
KURITA, T
中科院分区：
文献类型：
--
作者：
KOHRI, K;TAKADA, M;KURITA, T
我们观察了复发性钙结石患者单用别嘌醇、单用噻嗪及两药合用18个月以上时血、尿成分的变化，并与未用药者进行了比较。别嘌醇组治疗后1~2年血、尿尿酸均下降，甲状旁腺激素(PTH)和尿钙升高。噻嗪治疗3个月后血钙下降，但仍未达到治疗前水平，随后逐渐升高。尿钙在治疗3个月后下降，但在治疗6个月和12个月时恢复到治疗前水平。血浆甲状旁腺素逐渐升高。在接受别嘌醇和噻嗪联合治疗的患者中，血和尿尿酸、血钾和尿钙在治疗过程中均降低。血浆甲状旁腺素在治疗过程中逐渐升高。在没有接受治疗的患者中，血浆和尿液的成分在随访期间没有改变。并对尿钙和血浆甲状旁腺素变化的原因进行了讨论。
We have investigated the composition of plasma and urine in patients with recurrent calcium calculi treated with allopurinol alone, thiazide alone, and both agents together for more than 18 months, and compared the results with those of patients receiving no treatment. In patients treated with allopurinol, both plasma and urinary uric acid were decreased, and plasma parathyroid hormone (PTH) and urinary calcium were increased between 1 and 2 years after treatment. In patients treated with thiazide, plasma calcium was decreased 3 months after treatment but then increased gradually, although the pre-treatment level was not reached. Urinary calcium was decreased 3 months after treatment but returned to pre-treatment levels at 6 and 12 months. Plasma PTH was gradually increased. In patients treated with both allopurinol and thiazide, plasma and urinary uric acid, plasma potassium and urinary calcium were decreased during treatment. Plasma PTH increased gradually during treatment. In patients receiving no treatment, the composition of plasma and urine did not alter during follow-up. The reasons for the changes in urinary calcium and plasma PTH have been discussed.