PATHOLOGY OF EXPERIMENTAL EBOLA VIRUS-INFECTION IN MONKEYS
PATHOLOGY OF EXPERIMENTAL EBOLA VIRUS-INFECTION IN MONKEYS
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DOI：
10.1002/path.1711250303
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发表时间：
1978-01-01
影响因子：
7.3
通讯作者：
SIMPSON, DIH
中科院分区：
文献类型：
--
作者：
BASKERVILLE, A;BOWEN, ETW;SIMPSON, DIH
6只恒河猴和2只长尾猴感染了埃博拉病毒。4天后出现急性出血热伴皮疹，感染后6-12天死亡。肝、脾、淋巴结、肺、睾丸均可见急性坏死的组织病理学病变。在几个器官中出现纤维蛋白血栓提示感染期间发生弥散性血管内凝血。
Six rhesus and 2 vervet monkeys were infected i.p. with Ebola virus. They developed an acute hemorrhagic fever with skin rash 4 days later and died 6-12 days after infection. Histopathological lesions of acute necrosis were present in the liver, spleen, lymph nodes, lungs and testes. The presence of fibrin thrombi in several organs suggested the occurrence of disseminated intravascular coagulation during the infection.