Cardiorespiratory events in preterm infants: interventions and consequences
Cardiorespiratory events in preterm infants: interventions and consequences
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DOI：
10.1038/jp.2015.165
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
MacFarlane, P.
中科院分区：
文献类型：
--
作者：
Di Fiore, J. M.;Poets, C. F.;MacFarlane, P.
呼吸和氧合的稳定仍然是新生儿临床护理的主要挑战之一。尽管积极的呼吸支持，包括机械通气，持续气道正压通气，氧气和咖啡因治疗，以减少呼吸暂停和伴随的间歇性低氧血症，间歇性低氧血症事件的发生率继续增加，在生命的最初几个月。即使在临床护理方面有所改善，在这一脆弱的婴儿群体中，氧饱和度目标标准和呼吸支持模式尚未确定。此外，我们刚刚开始探索出生后早期心肺事件的发生率和模式与短期和长期发病率（包括早产儿视网膜病变、生长、睡眠呼吸障碍和神经发育障碍）之间的相关性。本综述的第1部分包括肺发育和心肺监测诊断方法的总结。在第2部分中，我们重点关注早产儿心肺事件的临床干预和短期和长期后果。
Stabilization of respiration and oxygenation continues to be one of the main challenges in clinical care of the neonate. Despite aggressive respiratory support including mechanical ventilation, continuous positive airway pressure, oxygen and caffeine therapy to reduce apnea and accompanying intermittent hypoxemia, the incidence of intermittent hypoxemia events continues to increase during the first few months of life. Even with improvements in clinical care, standards for oxygen saturation targeting and modes of respiratory support have yet to be identified in this vulnerable infant cohort. In addition, we are only beginning to explore the association between the incidence and pattern of cardiorespiratory events during early postnatal life and both short- and long-term morbidity including retinopathy of prematurity, growth, sleep-disordered breathing and neurodevelopmental impairment. Part 1 of this review included a summary of lung development and diagnostic methods of cardiorespiratory monitoring. In Part 2 we focus on clinical interventions and the short- and long-term consequences of cardiorespiratory events in preterm infants.