OLFACTORY MECHANISMS IN THE CONTROL OF MATERNAL AGGRESSION, APPETITE, AND FEARFULNESS - EFFECTS OF LESIONS TO OLFACTORY RECEPTORS, MEDIODORSAL THALAMIC NUCLEUS, AND INSULAR PREFRONTAL CORTEX
OLFACTORY MECHANISMS IN THE CONTROL OF MATERNAL AGGRESSION, APPETITE, AND FEARFULNESS - EFFECTS OF LESIONS TO OLFACTORY RECEPTORS, MEDIODORSAL THALAMIC NUCLEUS, AND INSULAR PREFRONTAL CORTEX
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DOI：
10.1037/0735-7044.101.5.709
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发表时间：
1987-10-01
影响因子：
1.9
通讯作者：
HANSEN, S
中科院分区：
文献类型：
--
作者：
FERREIRA, A;DAHLOF, LG;HANSEN, S
在哺乳期，雌性大鼠是hyperphagic，对成年同种动物的侵略性，比平常更少的恐惧。在第一个实验中，通过手术切除鼻腔的嗅上皮来研究嗅觉受体的重要性。与假手术雌性大鼠相比，接受该处理的母鼠消耗的食物显著更少，体重也更轻。此外，实验对象表现出显着减少母亲的侵略。另一方面，恐惧行为（声音引起的冻结）不受病变的影响。丘脑背内侧核和前额叶岛叶皮层构成了中枢嗅觉系统的一部分。第二个实验评估了这种嗅觉相关的丘脑皮质系统对母鼠行为的影响。结果发现，虽然丘脑和皮质病变离开食物摄入和恐惧行为不受影响，他们显着降低的频率，母亲会攻击一个入侵者男性放在她的家笼。根据目前的实验，嗅觉似乎在母性攻击中起着至关重要的作用。
During lactation the female rat is hyperphagic, aggressive toward adult conspecifics, and less fearful than usual. In the first experiment the important of olfactory receptors was investigated by surgically removing the olfactory epithelium of the nasal cavity. Mother rats subjected to this treatment consumed significantly less food and weighed less than sham-operated females. Moreover, experimental subjects displayed a dramatic decrease in maternal aggression. Fear behavior (sound-elicited freezing), on the other hand, was not affected by the lesions. The mediodorsal thalamic nucleus and the prefrontal insular cortex form part of the central olfactory system. The second experiment assessed the involvement of this olfactory-related thalamocortical system on the behavioral profile of mother rats. It was found that whereas the thalamic and cortical lesions left food intake and fear behavior unaffected, they significantly decreased the frequency with which the mother would attack an intruder male placed into her home cage. The sense of smell appears, according to the present experiments, to play a crucial role in maternal aggression.