Genomic approaches to research in pulmonary hypertension.
Genomic approaches to research in pulmonary hypertension.
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DOI：
10.1186/rr59
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发表时间：
2001
影响因子：
5.8
通讯作者：
Voelkel NF
中科院分区：
文献类型：
--
作者：
Geraci MW;Gao B;Hoshikawa Y;Yeager ME;Tuder RM;Voelkel NF
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of pulmonary hypertension (PH). Candidate genes, important to the pathobiology of the disease, have been investigated. Rodent models enable the manipulation of selected genes, either by transgenesis or targeted disruption. Mutational analysis of genes in the transforming growth factor-β family have proven pivotal in both familial and sporadic forms of primary PH. Finally, microarray gene expression analysis is a robust molecular tool to aid in delineating the pathobiology of this disease.
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通讯作者：
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