Effect of prolactin and growth hormone on prolactin and LH receptors in the dwarf mouse.
Effect of prolactin and growth hormone on prolactin and LH receptors in the dwarf mouse.
复制标题
催乳素和生长激素对侏儒小鼠催乳素和 LH 受体的影响。
DOI：
10.1530/jrf.0.0480307
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
H. Friesen
中科院分区：
文献类型：
--
作者：
H. Bohnet;H. Friesen
Dwarf mice (DW/J;dw/dw) which exhibit a deficiency of prolactin and GH secretion were treated for 8 days with ovine prolactin and/or human GH (10 or 20 mug/day) and the effect on hepatic and testicular prolactin receptors was investigated. In both sexes there was a significant increase in body weight after all hormone treatments, but an increment in testicular weight was observed only after prolactin administration. Prolactin treatment increased the specific binding % of prolactin in liver membranes in females but not males, and in testicular homogenates (together with an increase in LH receptors). The results suggest that lack of prolactin but not of GH retards sexual development in these mice. Treatment with prolactin partly counteracts this deficiency, and the effect may be mediated by the induction of hepatic and testicular prolactin and LH receptors.
