NIGROSTRIATAL DOPAMINERGIC ACTIVITY IS INCREASED DURING EXHAUSTIVE EXERCISE STRESS IN RATS
NIGROSTRIATAL DOPAMINERGIC ACTIVITY IS INCREASED DURING EXHAUSTIVE EXERCISE STRESS IN RATS
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DOI：
10.1016/0024-3205(88)90011-2
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
COATES, G
中科院分区：
文献类型：
--
作者：
HEYES, MP;GARNETT, ES;COATES, G
运动能力受中枢多巴胺能活动的增加和减少的影响。为了研究运动应激对脑内多巴胺代谢的影响，使大鼠以37 m/min的速度在电动跑步机上跑不同的时间，直到在19.6 ± 1.5 m/min时力竭。0.6纹状体、脑干和下丘脑中多巴胺、DOPAC和HVA的浓度在力竭时增加。5-纹状体HIAA浓度升高，而下丘脑去甲肾上腺素浓度降低。结果表明，多巴胺能活性的延迟增加发生在运动过程中。这些和其他观察结果表明，中枢多巴胺能活动调节运动表现。
Exercise capacity is influenced by both increases and decreases in central dopaminergic activity. To investigate the effects of exercise stress on intracerebral dopamine metabolism, rats were run on a motor driven treadmill at 37 m/min for varying times up to exhaustion at 19.6 .+-. 0.6 min. Dopamine, DOPAC, and HVA concentrations in striatum, brain stem, and hypothalamus increased towards exhaustion. 5-HIAA concentrations increased in striatum whereas norepinephrine concentrations decreased in hypothalamus. The results indicate that delayed increases in dopaminergic activity occurs during exercise. These, and other observations indicate that central dopaminergic activity modulates exercise performance.