Performance assessment of an opto-fluidic phantom mimicking porcine liver parenchyma.
Performance assessment of an opto-fluidic phantom mimicking porcine liver parenchyma.
复制标题
模拟猪肝实质的光流控模型的性能评估。
DOI：
10.1117/1.jbo.17.7.077008
复制
发表时间：
2012
影响因子：
3.5
通讯作者：
Coté,GerardL
中科院分区：
文献类型：
--
作者：
Akl,TonyJ;King,TravisJ;Long,Ruiqi;McShane,MichaelJ;NanceEricson,M;Wilson,MarkA;Coté,GerardL
目前正在开发一种植入式光学氧合和灌注传感器，用于在移植手术后两周内监测肝脏移植。为了最大限度地减少本研究所需的动物实验的数量，正在开发一种模拟肝实质的光学，解剖和生理流动特性的体模。在这项工作中，该模型的适用性肝实质灌注研究进行了评估，通过直接比较的模型灌注数据与数据收集fromin vivoporcine研究，都使用相同的原型灌注sensor.In体外灌注和闭塞实验进行了单层和三层模型灌注具有吸收特性的氧合血红蛋白的染料溶液。虽然两种模型都表现出与肝实质相似的反应模式，但从多层模型测得的信号比单层模型高出3倍，对灌注的体外变化敏感性高出约21%。虽然多层体模更接近地复制了体内的低模式，但数据表明，两种体模都可以在体外用于促进传感器设计。
An implantable, optical oxygenation and perfusion sensor to monitor liver transplants during the two-week period following the transplant procedure is currently being developed. In order to minimize the number of animal experiments required for this research, a phantom that mimics the optical, anatomical, and physiologic flow properties of liver parenchyma is being developed as well. In this work, the suitability of this phantom for liver parenchyma perfusion research was evaluated by direct comparison of phantom perfusion data with data collected fromin vivoporcine studies, both using the same prototype perfusion sensor.In vitroperfusion and occlusion experiments were performed on a single-layer and on a three-layer phantom perfused with a dye solution possessing the absorption properties of oxygenated hemoglobin. While both phantoms exhibited response patterns similar to the liver parenchyma, the signal measured from the multilayer phantom was three times higher than the single layer phantom and approximately 21 percent more sensitive toin vitrochanges in perfusion. Although the multilayer phantom replicated thein vivoflow patterns more closely, the data suggests that both phantoms can be usedin vitroto facilitate sensor design.