Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation
Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation
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DOI：
10.1007/s10654-004-5760-z
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发表时间：
2004-10-01
影响因子：
13.6
通讯作者：
Kardinaal, AFM
中科院分区：
文献类型：
--
作者：
van Herpen-Broekmans, WMR;Klöpping-Ketelaars, IAA;Kardinaal, AFM
背景：内皮细胞功能障碍可能与细胞氧化应激增加有关。类胡萝卜素和维生素可以通过抗氧化剂介导调节内皮功能和炎症，从而降低动脉粥样硬化的风险。方法：我们测量了从普通人群中抽取的 379 名受试者的血清类胡萝卜素、α-生育酚和维生素 C 浓度。测量高敏 C 反应蛋白 (CRP)、纤维蛋白原 (Fbg) 和白细胞作为炎症标志物。此外，测量可溶性细胞间粘附分子-1（sICAM-1）和血流介导的血管舒张（FMD；n = 165）作为内皮功能的标志物。调整混杂因素后，分析血清类胡萝卜素和维生素以及内皮功能和炎症标志物之间的关系。结果：在整个研究组中，叶黄素和番茄红素与 sICAM-1 呈负相关，回归系数分别为每 1 mumol/l -0.38 +/- 0.19 (p = 0.04) 和 0.16 +/- 0.08 (p = 0.04)。每 1 mumol/l β-胡萝卜素与白细胞 (-0.23 +/- 0.07；p = 0.007) 和 CRP (-1.09 +/- 0.30；p = 0.0003) 呈负相关。每 1 mumol/l 维生素 C 与 CRP 呈负相关（-0.01 +/- 0.005；p = 0.04），而每 1 muol/l α-生育酚与 CRP 呈正相关（0.03 +/- 0.01；p = 0.02）。每 1 微摩尔/升的玉米黄质与 FMD 呈负相关（31.2 +/- 15.3；p = 0.04）。结论：类胡萝卜素、维生素 C 与 sICAM-1、CRP 和白细胞之间的负相关关系可能有助于解释类胡萝卜素和维生素 C 通过影响炎症过程和内皮功能对动脉粥样硬化的可能保护作用。
Background: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. Methods: We measured serum carotenoids, alpha-tocopherol and Vitamin C concentrations in 379 subjects sampled from the general population. High-sensitive C-reactive protein (CRP), fibrinogen (Fbg) and leukocytes were measured as markers of inflammation. Furthermore, soluble intercellular adhesion molecule-1 (sICAM- 1) and flow-mediated vasodilation (FMD; n = 165) were measured as markers of endothelial function. Relationships between serum carotenoids and vitamins and markers of endothelial function and inflammation were analysed after adjustment for confounding. Results: In the total study group, lutein and lycopene were inversely related to sICAM- 1 with regression-coefficients of -0.38 +/- 0.19 (p = 0.04) and) 0.16 +/- 0.08 (p = 0.04) per 1 mumol/l, respectively. beta-Carotene was inverse related to leukocytes (-0.23 +/- 0.07; p = 0.007) and CRP (-1.09 +/- 0.30; p = 0.0003) per 1 mumol/l. Vitamin C was inverse related to CRP (-0.01 +/- 0.005; p = 0.04) per 1 mumol/l, whereas alpha-tocopherol was positively related to CRP (0.03 +/- 0.01; p = 0.02) per 1 mu/l. Zeaxanthin was inversely related to FMD (31.2 +/- 15.3; p = 0.04) per 1 mumol/l. Conclusion: The inverse relations between carotenoids, Vitamin C and sICAM- 1, CRP and leukocytes may help to explain the possible protective effect of carotenoids and Vitamin C on atherosclerosis through an influence on inflammatory processes and endothelial function.