GENETIC BASIS OF ADAPTATION IN ARABIDOPSIS THALIANA: LOCAL ADAPTATION AT THE SEED DORMANCY QTL DOG1
GENETIC BASIS OF ADAPTATION IN ARABIDOPSIS THALIANA: LOCAL ADAPTATION AT THE SEED DORMANCY QTL DOG1
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DOI：
10.1111/j.1558-5646.2012.01590.x
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发表时间：
2012-07-01
期刊：
影响因子：
3.3
通讯作者：
de Meaux, Juliette
中科院分区：
文献类型：
--
作者：
Kronholm, Ilkka;Xavier Pico, F.;de Meaux, Juliette
局部适应为研究适应的遗传基础和适应基因的等位结构提供了机会。我们研究延迟发芽1（DOG1），一个控制拟南芥种子休眠的自然变异的基因，并调查分布在四个地区的自然屏障分离的41个种群的休眠进化。使用FST和QST比较，我们比较了在DOG1的变化与中性标记和种子休眠的数量变化。种群间的遗传分化模式表明，基因DOG1有助于当地的适应。虽然种子休眠的QST与中性标记的FST没有不同，但与夏季降水变化的相关性支持种子休眠是适应性的。我们的特点在几个F2群体的休眠变化，并表明，一系列功能不同的等位基因分离在DOG1位点。理论模型表明，数量性状基因座（QTL）上等位基因分离的数量和效果对适应性有重要影响。我们的研究结果提供了支持的模型假设大量的等位基因在数量性状基因座参与适应。
Local adaptation provides an opportunity to study the genetic basis of adaptation and investigate the allelic architecture of adaptive genes. We study DELAY OF GERMINATION 1 (DOG1), a gene controlling natural variation in seed dormancy in Arabidopsis thaliana and investigate evolution of dormancy in 41 populations distributed in four regions separated by natural barriers. Using FST and QST comparisons, we compare variation at DOG1 with neutral markers and quantitative variation in seed dormancy. Patterns of genetic differentiation among populations suggest that the gene DOG1 contributes to local adaptation. Although QST for seed dormancy is not different from FST for neutral markers, a correlation with variation in summer precipitation supports that seed dormancy is adaptive. We characterize dormancy variation in several F2-populations and show that a series of functionally distinct alleles segregate at the DOG1 locus. Theoretical models have shown that the number and effect of alleles segregatin at quantitative trait loci (QTL) have important consequences for adaptation. Our results provide support to models postulating a large number of alleles at quantitative trait loci involved in adaptation.