Functional differences in forebrain auditory regions during learned vocal recognition in songbirds
Functional differences in forebrain auditory regions during learned vocal recognition in songbirds
复制标题
DOI：
10.1007/s00359-004-0556-x
复制
发表时间：
2004-12-01
影响因子：
2.1
通讯作者：
Ball, GF
中科院分区：
文献类型：
--
作者：
Gentner, TQ;Hulse, SH;Ball, GF
越来越多的证据表明，听觉前脑区域尾侧内侧中膜（cmHV）和尾侧内侧内膜参与了鸣禽同向发声的知觉加工。然而，人们对这些区域内更具体的处理过程知之甚少，尤其是在基于歌曲的感知行为中。尾侧内侧中膜和尾侧内侧内膜的一个特征是，它们对同类型歌曲的反应中强烈表达了立即早期基因zenk，这两个区域类似于哺乳动物的次级听觉皮层结构。通过训练欧洲椋鸟识别个体同种鸟的鸣叫声，研究人员发现，当鸣叫声识别需求被置于系统中时，尾端内侧内足部和尾端内侧中足部的zenk蛋白表达水平和模式不同。在尾侧内侧中膜，在熟悉歌曲的识别、熟悉歌曲的新联想的获得和新歌辨别的获得过程中，表达显著高于基础水平。然而，在尾侧内侧鞘中，只有在习得新歌辨别时，表达才显著高于基础水平。研究结果直接暗示，至少一部分听觉过程是由尾侧内侧内膜和尾侧内侧中膜参与的。此外，观察到的这些区域之间的差异表明，不同的听觉加工机制在尾侧内侧内膜和尾侧内侧中膜内的功能定位（或至少集中）。
Converging evidence implicates the auditory forebrain regions caudal medial mesopallium (formerly cmHV) and caudal medial nidopallium in the perceptual processing of conspecific vocalizations in songbirds. Little is known however, about more specific processing within these regions especially during song-based perceptual behaviors. One hallmark of the caudal medial mesopallium and caudal medial nidopallium, areas analogous to mammalian secondary auditory cortical structures, is their robust expression of the immediate-early-gene zenk in response to conspecific songs. Using European starlings operantly trained to recognize the songs of individual conspecifics, we show that the levels and patterns of zenk protein expression in the caudal medial nidopallium and caudal medial mesopallium differ when song recognition demands are placed on the system. In the caudal medial mesopallium, expression is significantly elevated above basal levels during the recognition of familiar songs, the acquisition of novel associations for familiar songs, and the acquisition of novel song discriminations. In the caudal medial nidopallium, however, expression is significantly elevated above basal levels only during the acquisition of novel song discriminations. The results directly implicate the caudal medial nidopallium and caudal medial mesopallium in at least a portion of the auditory processes underlying vocal recognition. Moreover, the observed differences between these regions imply the functional localization (or at least the concentration) of different auditory processing mechanisms within the caudal medial nidopallium and the caudal medial mesopallium.