Multiple novel transcription initiation sites for NRG1
Multiple novel transcription initiation sites for NRG1
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DOI：
10.1016/j.gene.2004.07.029
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发表时间：
2004-11-10
期刊：
影响因子：
3.5
通讯作者：
Gulcher, JR
中科院分区：
文献类型：
--
作者：
Steinthorsdottir, V;Stefansson, H;Gulcher, JR
大的神经调节蛋白I基因(Nrg1)位于染色体8p11-21上的1.125 Mb区域。已经描述了NRG1的三种主要形式(类型I-III)，它们都具有由独特的5‘-外显子编码的不同的氨基末端。我们发现了9个新的NRG1外显子，其中包括6个替代的5‘-外显子，使NRGI中潜在的启动子数量从3个增加到9个。这里描述的NRGI的新转录本使用了新的5‘-外显子，这些外显子要么是编码的，要么是非编码的。它们所编码的预测蛋白质的功能相关性还没有得到评估。三个新的Y-外显子在大鼠和小鼠的同线序列中被很好地保守；它们编码具有新的氨基端的蛋白质，在这里被称为IV-VI型。NRG1在神经发育中发挥着核心作用，很可能参与了突触可塑性的调节，也就是大脑如何对环境做出反应或适应。异常复杂的基因结构可能有助于NRG1表达的时空调节，微调NRG1蛋白在神经系统发育不同阶段的功能，并适应成人大脑对环境的反应。(C)2004爱思唯尔B.V.保留所有权利。
The large neuregulin I gene (NRG1) has been mapped to a 1.125 Mb region on chromosome 8p11-21. Three major forms of NRG1 (types I-III), all with distinct amino-termini encoded by unique 5'-exons, have been described. We report here the discovery of nine novel NRG1 exons, including six alternative 5'-exons, increasing the number of potential promoters in NRGI from three to nine. The novel transcripts of NRGI described here use the novel 5'-exons which are either coding or non-coding. The functional relevance of the predicted proteins they encode has not been evaluated. Three of the novel Y-exons are well conserved in syntenic rat and mouse sequences; they encode proteins with novel amino-termini, here termed types IV-VI. NRG1 plays a central role in neural development and is most likely involved in regulation of synaptic plasticity, or how the brain responds or adapts to the environment. The unusually complex gene structure may facilitate spatial and temporal regulation of NRG1 expression, fine-tune NRG1 protein function at different stages during development of the nervous system, and adapt responses to the environment in the adult brain. (C) 2004 Elsevier B.V. All rights reserved.