Periodontal infections and pre-term low birth weight:: a case-control study
Periodontal infections and pre-term low birth weight:: a case-control study
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DOI：
10.1111/j.1600-051x.2005.00670.x
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发表时间：
2005-02-01
影响因子：
6.7
通讯作者：
Dahlen, G
中科院分区：
文献类型：
--
作者：
Buduneli, N;Baylas, H;Dahlen, G
目的：早产低出生体重儿[早产低出生体重儿（PLBW）]仍然是一个重要的公共卫生问题，也是新生儿死亡和长期健康问题的主要原因。越来越多的人认为，远离胎儿-胎盘单位的感染可能会影响PLBW婴儿。最近的研究表明，母亲牙周病可能是一个独立的危险因素PLBW。本研究的目的是评估牙周感染和PLBW之间的可能联系，通过临床和微生物学数据在产后妇女低社会经济水平。方法：临床牙周记录包括牙菌斑、探诊出血，在产后3天内对总共181名妇女（53例和128例对照）进行了牙周袋深度探查和牙龈退缩（6个部位/牙齿）。龈下菌斑样品从近中或远颊面随机选择一个第一磨牙和一个切牙已获得纸点和棋盘DNA-DNA杂交分析12种细菌。在所有分析中，个体受试者是计算单位。因此，计算所有临床参数的平均值，并对每个单独样品的细菌评分取平均值。统计方法包括t检验、Fisher精确检验/卡方检验和多元Logistic回归分析。对照组龈下菌斑采样部位牙龈卟啉单胞菌、中间普雷沃菌、变黑普雷沃菌、伴放线放线杆菌和中间链球菌的平均和中位评分（细菌载量）显著高于病例组（p 0. 05）。根据多元Logistic回归分析建立的模型，小球藻和C.腹直肌明显增加PLBW的风险（p
Objective: Pre-term delivery of low-birth-weight infants [pre-term low birth weight (PLBW)] remains a significant public health issue and a major cause of neonatal death and long-term health problems. There is a growing consensus that infections remote from fetal-placental unit may influence PLBW infants. Recent studies have suggested that maternal periodontal disease may be an independent risk factor for PLBW. The purpose of the present study was to evaluate the possible link between periodontal infections and PLBW by means of clinical and microbiological data in post-partum women with low socioeconomic level.Methods: Clinical periodontal recordings comprising dental plaque, bleeding on probing, probing pocket depth and gingival recession were performed (six sites/tooth) in a total number of 181 women (53 cases and 128 controls) within 3 days post-partum. Subgingival plaque samples from mesio-or disto-buccal aspect of randomly selected one first molar and one incisor tooth have been obtained by paperpoints and were analysed by checkerboard DNA-DNA hybridization with respect to 12 bacterial species. In all analyses, the individual subject was the computational unit. Thus, mean values for all clinical parameters were calculated and bacterial scores from each individual sample were averaged. Statistical methods included Student's t-test, Fisher's exact test/chi(2) test, and multiple logistic regression analysis.Results: The cases have gained significantly less weight during the pregnancy than did the controls (p0.05). Mean and median scores (bacterial loads) of Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Actinobacillus actinomycetemcomitans, and Streptococcus intermedius in the subgingival plaque sampling sites were significantly higher in the controls than in the cases (p0.05). According to the model created by the multiple logistic regression analysis, P. micros and C. rectus were found to significantly increase the risk of PLBW (p