Stable cerasomes for simultaneous drug delivery and magnetic resonance imaging.
Stable cerasomes for simultaneous drug delivery and magnetic resonance imaging.
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用于同时药物输送和磁共振成像的稳定陶瓷体。
DOI：
10.2147/ijn.s66919
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发表时间：
2014
影响因子：
8
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Cao Z;Zhu W;Wang W;Zhang C;Xu M;Liu J;Feng ST;Jiang Q;Xie X
近年来，磁性脂质体作为纳米载体被广泛应用于靶向给药和磁共振成像等领域。尽管具有巨大的潜力，但它们在生理环境中的形态/结构不稳定性仍然是临床应用的棘手挑战。在这项研究中，稳定的混合脂质体神经酰胺脂质体（即脂质体部分包覆二氧化硅），可以共同封装Fe 3 O 4纳米粒子和抗癌药物紫杉醇使用薄膜水合法。与载药脂质体相比，紫杉醇磁性神经酰胺脂质体具有更高的储存稳定性和更好的缓释性能。细胞摄取研究表明，利用外部磁场显着促进PLMCs内化到癌细胞中，从而增强药物杀伤肿瘤细胞的功效。我们的PLMCs的T2弛豫率（r2）远高于游离Fe 3 O 4纳米颗粒，表明T2加权成像的灵敏度增加。鉴于其优异的生物相容性，这种双功能PLMC可能是一种有前途的纳米系统，用于有效的癌症诊断和治疗。
Magnetic liposomes have been frequently used as nanocarriers for targeted drug delivery and magnetic resonance imaging in recent years. Despite great potentials, their morphological/structural instability in the physiological environment still remains an intractable challenge for clinical applications. In this study, stable hybrid liposomal cerasomes (ie, liposomes partially coated with silica) which can co-encapsulate Fe3O4 nanoparticles and the anticancer drug paclitaxel were developed using thin film hydration method. Compared with the drug loaded liposomes, the paclitaxel-loaded magnetic cerasomes (PLMCs) exhibited much higher storage stability and better sustained release behavior. Cellular uptake study showed that the utilization of an external magnetic field significantly facilitated the internalization of PLMCs into cancer cells, resulting in potentiated drug efficacy of killing tumor cells. The T2 relaxivity (r2) of our PLMCs was much higher than that of free Fe3O4 nanoparticles, suggesting increased sensitivity in T2-weighted imaging. Given its excellent biocompatibility also shown in the study, such dual functional PLMC is potentially a promising nanosystem for effective cancer diagnosis and therapy.