Publisher Correction: Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management.
Publisher Correction: Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management.
复制标题
出版商更正：除草剂混合物的综合抗性的演变揭示了抗性管理的权衡。
DOI：
10.1038/s41467-020-18079-3
复制
发表时间：
2020
影响因子：
16.6
通讯作者：
Comont D
中科院分区：
文献类型：
--
作者：
Comont D
杀虫剂和抗生素的激烈选择导致了进化耐药性的全球流行。在农业和医药领域，使用不同类别化合物的混合物被广泛接受为最佳的耐药性管理。然而，这种策略可能会促进更普遍的抗性机制的进化。在这里，我们在全国范围内对一种具有重要经济意义的农业杂草——黑草（Alopecurus myosuroides）进行了测试，对其除草剂抗性是一个主要的经济问题。我们的研究结果表明，使用较多的除草剂混合物与较低水平的专业抗性机制有关，但与多种作用模式的除草剂代谢增强有关的通用机制水平较高。我们的研究结果表明，在抗性管理中存在潜在的进化权衡，即试图减少对特殊抗性性状的选择可能会促进通才抗性的进化。我们认为，当专家和通才耐药机制共同出现时，类似的权衡将是显而易见的，这就对基于混合和联合治疗的普遍耐药管理提出了质疑。
Intense selection by pesticides and antibiotics has resulted in a global epidemic of evolved resistance. In agriculture and medicine, using mixtures of compounds from different classes is widely accepted as optimal resistance management. However, this strategy may promote the evolution of more generalist resistance mechanisms. Here we test this hypothesis at a national scale in an economically important agricultural weed: blackgrass (Alopecurus myosuroides), for which herbicide resistance is a major economic issue. Our results reveal that greater use of herbicide mixtures is associated with lower levels of specialist resistance mechanisms, but higher levels of a generalist mechanism implicated in enhanced metabolism of herbicides with diverse modes of action. Our results indicate a potential evolutionary trade-off in resistance management, whereby attempts to reduce selection for specialist resistance traits may promote the evolution of generalist resistance. We contend that where specialist and generalist resistance mechanisms co-occur, similar trade-offs will be evident, calling into question the ubiquity of resistance management based on mixtures and combination therapies.