Circadian modulation in the rat acoustic startle circuit.
Circadian modulation in the rat acoustic startle circuit.
复制标题
大鼠声惊吓电路中的昼夜节律调制。
作者：
P. Frankland;M. Ralph
大鼠的声惊吓反射（ASR）表现出强大的昼夜节律调节，在主观夜间ASR幅度更大。为了确定这种调制的位置，通过植入主ASR电路中的电极以声学或电学方式诱发惊吓反应。在昼夜节律周期的不同时间比较惊吓幅度。在恒定的环境条件下，惊吓幅度更大，在主观的夜晚声诱发和电诱发的反应，从腹侧丘系和内侧纵束。结果表明，在脑桥尾侧网状结构的最后一个脑干突触之后的回路中的某个点，在脊髓中间神经元或运动神经元水平或在神经肌肉接头处，至少有一个昼夜节律调制位点。
The acoustic startle reflex (ASR) in rats exhibits robust circadian modulation, with ASR amplitudes greater during subjective night. To identify the location of this modulation, startle reactions were evoked either acoustically or electrically via electrodes implanted in the primary ASR circuit. Startle amplitudes were compared at different times in the circadian cycle. In constant environmental conditions, startle amplitudes were greater in subjective night for acoustically evoked and for electrically evoked reactions from the ventral lateral lemniscus and medial longitudinal fasciculus. The results show that at least 1 site of circadian modulation must occur at some point in the circuit after the last brainstem synapse in the caudal pontine reticular formation, at the level of spinal interneurons or motoneurons or at the neuromuscular junction.